Ethyl 5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate

Base Information

Chemical Name:Ethyl 5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate
CAS No.:87273-80-1
Molecular Formula:C₁₁H₁₃NO₃
Molecular Weight:207.229
Hs Code.:
DSSTox Substance ID:DTXSID80518496
Nikkaji Number:J1.217.380F
Wikidata:Q82381202
Mol file:87273-80-1.mol

Synonyms:ETHYL 5-OXO-1,2,3,5-TETRAHYDROINDOLIZINE-8-CARBOXYLATE;87273-80-1;SCHEMBL698338;DTXSID80518496

Suppliers and Price of Ethyl 5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

American Custom Chemicals Corporation
5-OXO-1,2,3,5-TETRAHYDRO-INDOLIZINE-8-CARBOXYLIC ACID ETHYL ESTER 95.00%
5MG
$ 496.01

Total 2 raw suppliers

Chemical Property of Ethyl 5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate

Chemical Property:

XLogP3:0.7
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:207.08954328
Heavy Atom Count:15
Complexity:368

Purity/Quality:: 5-OXO-1,2,3,5-TETRAHYDRO-INDOLIZINE-8-CARBOXYLIC ACID ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=C2CCCN2C(=O)C=C1

Technology Process of Ethyl 5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate

There total 4 articles about Ethyl 5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 35150-22-2
(Z)-ethyl 2-(pyrrolidin-2-ylidene)acetate

: 623-47-2
propynoic acid ethyl ester

: 87273-80-1
ethyl 5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate

Guidance literature:: In toluene; for 144h; Heating;
DOI:10.1016/S0040-4020(99)00937-0

Reference yield: 13.0%

: 35150-22-2
(Z)-ethyl 2-(pyrrolidin-2-ylidene)acetate

: 78-94-4,25038-87-3
methyl vinyl ketone

: 87273-80-1
ethyl 5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate

Guidance literature:: In benzene; for 158h; Heating;

Reference yield:

: 35150-22-2
(Z)-ethyl 2-(pyrrolidin-2-ylidene)acetate

: 87273-80-1
ethyl 5-oxo-1,2,3,5-tetrahydroindolizine-8-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 74 percent / ethanol / 16 h / Heating

2: 63 percent / sodium ethoxide / ethanol / 2 h / Heating

sodium ethanolate; In ethanol; 1: Addition / 2: Isomerization;
DOI:10.1016/S0040-4020(99)00937-0