N-acetyl-2-(4'-chlorophenyl)-1,2,3,4-tetrahydro-4-quinolone

Base Information

• Chemical Name: N-acetyl-2-(4'-chlorophenyl)-1,2,3,4-tetrahydro-4-quinolone
• CAS No.: 144709-14-8
• Molecular Formula: C₁₇H₁₄ClNO₂
• Molecular Weight: 299.757
• Mol file: 144709-14-8.mol

Synonyms:N-acetyl-2-(4'-chlorophenyl)-1,2,3,4-tetrahydro-4-quinolone

Chemical Property of N-acetyl-2-(4'-chlorophenyl)-1,2,3,4-tetrahydro-4-quinolone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-acetyl-2-(4'-chlorophenyl)-1,2,3,4-tetrahydro-4-quinolone

There total 1 articles about N-acetyl-2-(4'-chlorophenyl)-1,2,3,4-tetrahydro-4-quinolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

acetic anhydride (108-24-7) + 2-(4-chlorophenyl)-2,3-dihydroquinolin-4(1H)-one (147463-98-7) → N-acetyl-2-(4'-chlorophenyl)-1,2,3,4-tetrahydro-4-quinolone (144709-14-8)

Guidance literature:

With acetic acid; for 1h; Heating;

DOI:10.1080/00397910500466462

Reference yield: 72.0%

N-acetyl-2-(4'-chlorophenyl)-1,2,3,4-tetrahydro-4-quinolone (144709-14-8) + [hydroxy(tosyloxy)iodo]benzene (27126-76-7) + trimethyl orthoformate (149-73-5) → C18H16ClNO3 + methyl p-toluene sulfonate (80-48-8)

Guidance literature:

at 30 ℃; for 1h;

DOI:10.3184/030823407X270329

Reference yield: 70.0%

N-acetyl-2-(4'-chlorophenyl)-1,2,3,4-tetrahydro-4-quinolone (144709-14-8) + trimethyl orthoformate (149-73-5) → trans-methyl N-acetyl-2-(4'-chlorophenyl)-2,3-dihydroindol-3-carboxylate + 2-(4'-chlorophenyl)-4-methoxyquinoline

Guidance literature:

N-acetyl-2-(4'-chlorophenyl)-1,2,3,4-tetrahydro-4-quinolone; trimethyl orthoformate; With perchloric acid; at 20 ℃; for 0.25h;

With thallium(III) nitrate trihydrate; at 20 ℃; for 1h;

DOI:10.1080/00397910500466462

upstream raw materials:

acetic anhydride

2-(4-chlorophenyl)-2,3-dihydroquinolin-4(1H)-one

Downstream raw materials:

methyl p-toluene sulfonate