147463-98-7

Basic information

• Product Name: 2-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDRO-4-QUINOLONE
• Synonyms: 2-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDRO-4-QUINOLONE;2-(4-chlorophenyl)-2,3-dihydroquinolin-4(1H)-one
• CAS NO: 147463-98-7
• Molecular Formula: C₁₅H₁₂ClNO
• Molecular Weight: 257.71
• Mol File: 147463-98-7.mol
• Article Data: 31

Chemical Properties

• Melting Point: 168 °C
• Boiling Point: 434.907°C at 760 mmHg
• Flash Point: 216.824°C
• Appearance: /
• Density: 1.258g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.612
• Storage Temp.: 2-8°C
• PKA: 1.74±0.40(Predicted)
• CAS DataBase Reference: 2-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDRO-4-QUINOLONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDRO-4-QUINOLONE(147463-98-7)
• EPA Substance Registry System: 2-(4-CHLOROPHENYL)-1,2,3,4-TETRAHYDRO-4-QUINOLONE(147463-98-7)

Safety Data

• Hazardous Substances Data: 147463-98-7(Hazardous Substances Data)

Usage

Heterocyclic structure

The compound has a core structure that contains a ring of carbon and nitrogen atoms.

Tetrahydro-4-quinolone core

The compound has a four-carbon chain attached to a quinone ring, which is a chemical structure with two oxygen atoms attached to a carbon atom.

4-Chlorophenyl group

The compound has a chlorine atom attached to a phenyl ring (a ring of six carbon atoms with alternating single and double bonds), which is attached to the tetrahydro-4-quinolone core.

Pharmaceutical industry use

The compound is used as a potential drug candidate for various therapeutic applications.

Anti-inflammatory properties

The compound is known to reduce inflammation in the body.

Analgesic properties

The compound is known to relieve pain.

Anticonvulsant properties

The compound is known to prevent or reduce the severity of seizures.

Interesting subject for study

The unique structure and potential biological activities of the compound make it an interesting subject for further study and exploration in the field of medicinal chemistry.

InChI:InChI=1/C15H12ClNO/c16-11-7-5-10(6-8-11)14-9-15(18)12-3-1-2-4-13(12)17-14/h1-8,14,17H,9H2

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 551-93-9 2-aminoacetophenone 
• 958261-73-9 C₁₅H₁₂ClNO 
• 156492-26-1 trans-1-(2-aminophenyl)-3-(4-chlorophenyl)-prop-2-en-1-one 
• 1425928-62-6 C₁₇H₁₄ClNO₂ 
• 69511-65-5 trans-3-(4-chlorophenyl)-1-(2-nitrophenyl)prop-2-en-1-one 
• 5234-26-4 N-(2-acetylphenyl)acetamide 
• 118-92-3 anthranilic acid 
• 1450853-30-1 C₁₇H₁₄ClNO₂ 

Downstream Products

• 1171953-07-3 2-(4-chlorophenyl)-3-((pyridin-4-yl)methyl)quinolin-4(1H)-one 
• 1372870-96-6 C₂₃H₁₈ClNO₃ 
• 1372870-95-5 C₂₅H₁₆ClNO 
• 1372870-94-4 C₂₅H₁₆ClNO 
• 1171953-52-8 6,8-dibromo-2-(4-chlorophenyl)-2,3-dihydroquinolin-4(1H)-one 
• 1332337-69-5 2-(4-chlorophenyl)-4-methoxy-6,8-diphenylquinoline 

Relevant articles and documents

P -TsOH-promoted synthesis of (E)-6-phenyl-7-styryl-5,6-dihydrodibenzo [b, h] [1,6]naphthyridines via cascade intramolecular aza-Michael addition/Friedlander condensation of 2′-aminochalcones in a SDS/H2O system

Br?nsted acid-promoted cascade synthesis of novel (E)-6-phenyl-7-styryl-5,6-dihydrodibenzo[b,h][1,6]naphthyridines has been achieved via homodimerization of 2′-aminochalcones by employing sodium dodecylsulphate (SDS) as a surfactant in water. Besides water as an environmentally benign reaction medium, the reaction proceeds smoothly with high atom-economy under a sequential one-pot protocol.

2-aryl-2,3-dihydro-4(1H)-quinolinone semicarbazone compound and application thereof

The invention relates to the field of medicine technology, and a series of novel 2-aryl-2,3-dihydrogen-4(1H)-quinolinone semicarbazone derivatives (I) and pharmaceutically acceptable salts, solvates,optical isomers or polymorphs are designed and synthesized. The derivative (I) and its pharmaceutically acceptable salt, solvate, optical isomer or polymorph can be mixed as an active ingredient witha pharmaceutically acceptable carrier to prepare a pharmaceutical composition. A double dilution method is used for test of the antifungal activity of the derivative (I) and its pharmaceutically acceptable salt, solvate, optical isomer or polymorph, and the results show that the derivative has stronger killing effect on clinically common pathogenic fungi, and is expected to overcome the defects oflarge toxic and side effects, easy generation of drug resistance of azole antifungal medicines which are widely used clinically. The specific formula is shown in the description.

Silica-gel-supported Ce(SO4)2·4H2O-mediated cyclization of 2′-amino and 2′-hydroxychalcones under solvent-free conditions

A simple, efficient, and environmentally friendly approach for the synthesis of flavones, aza-flavones, and aza-flavanones from corresponding 2′-hydroxy or 2′-aminochalcones has been developed. The reactions are successfully conducted in presence of silica-gel-supported Ce(SO4)2·4H2O under solvent-free conditions.