3-tert-butoxycarbonylaminopyrrolidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

Base Information

Chemical Name:3-tert-butoxycarbonylaminopyrrolidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester
CAS No.:1589084-56-9
Molecular Formula:C₂₅H₂₈N₂O₆
Molecular Weight:452.507
Hs Code.:

Synonyms:3-tert-butoxycarbonylaminopyrrolidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

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Chemical Property of 3-tert-butoxycarbonylaminopyrrolidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

Chemical Property:

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Technology Process of 3-tert-butoxycarbonylaminopyrrolidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

There total 1 articles about 3-tert-butoxycarbonylaminopyrrolidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 869786-49-2
3-((tert-butoxycarbonyl)amino)pyrrolidine-3-carboxylic acid

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1589084-56-9
3-tert-butoxycarbonylaminopyrrolidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: With sodium carbonate; In 1,4-dioxane; water; at 20 ℃; for 2h; Cooling with ice;

Reference yield: 92.0%

: 1589084-56-9
3-tert-butoxycarbonylaminopyrrolidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

: 62-53-3
aniline

: 1589084-60-5
3-tert-butoxycarbonylamino-3-phenylcarbamoylpyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: 3-tert-butoxycarbonylaminopyrrolidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester; aniline; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; for 0.166667h;

With N,N-dimethyl-formamide; In tetrahydrofuran; for 1.5h;

Reference yield:

: 1589084-56-9
3-tert-butoxycarbonylaminopyrrolidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

: 1588952-05-9
3-amino-1-(5-methoxy-2-pyridin-4-ylpyrido[3,4-d]pyrimidin-4-yl)pyrrolidine-3-carboxylic acid phenylamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 0.17 h

1.2: 1.5 h

2.1: piperidine / methanol / 72 h

3.1: 2,4,6-triisopropylphenylsulfonyl chloride; triethylamine; dmap / N,N-dimethyl-formamide / 1 h / 20 °C

3.2: 20 °C

4.1: trifluoroacetic acid / dichloromethane / 2.5 h / 20 °C

With piperidine; dmap; 2,4,6-triisopropylphenylsulfonyl chloride; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;