3-tert-butoxycarbonylamino-3-phenylcarbamoylpyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Base Information

Chemical Name:3-tert-butoxycarbonylamino-3-phenylcarbamoylpyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester
CAS No.:1589084-60-5
Molecular Formula:C₃₁H₃₃N₃O₅
Molecular Weight:527.62
Hs Code.:

Synonyms:3-tert-butoxycarbonylamino-3-phenylcarbamoylpyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Chemical Property of 3-tert-butoxycarbonylamino-3-phenylcarbamoylpyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

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Technology Process of 3-tert-butoxycarbonylamino-3-phenylcarbamoylpyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

There total 3 articles about 3-tert-butoxycarbonylamino-3-phenylcarbamoylpyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1589084-56-9
3-tert-butoxycarbonylaminopyrrolidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester

: 62-53-3
aniline

: 1589084-60-5
3-tert-butoxycarbonylamino-3-phenylcarbamoylpyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: 3-tert-butoxycarbonylaminopyrrolidine-1,3-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester; aniline; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; for 0.166667h;

With N,N-dimethyl-formamide; In tetrahydrofuran; for 1.5h;

Reference yield:

: 869786-49-2
3-((tert-butoxycarbonyl)amino)pyrrolidine-3-carboxylic acid

: 1589084-60-5
3-tert-butoxycarbonylamino-3-phenylcarbamoylpyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / water; 1,4-dioxane / 2 h / 20 °C / Cooling with ice

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 0.17 h

2.2: 1.5 h

With sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: 1589084-60-5
3-tert-butoxycarbonylamino-3-phenylcarbamoylpyrrolidine-1-carboxylic acid 9H-fluoren-9-ylmethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium carbonate / water; 1,4-dioxane / 2 h / 20 °C / Cooling with ice

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / tetrahydrofuran / 0.17 h

2.2: 1.5 h

With sodium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; 1,4-dioxane; water;