(r)-1-(((9h-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

Base Information

• Chemical Name: (r)-1-(((9h-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid
• CAS No.: 105751-19-7
• Molecular Formula: C21H21NO4
• Molecular Weight: 351.402
• Hs Code.: 2933399090
• European Community (EC) Number: 624-385-5,631-279-2
• DSSTox Substance ID: DTXSID901314811
• Nikkaji Number: J791.551I
• Mol file: 105751-19-7.mol

Synonyms:101555-63-9;fmoc-d-pipecolic acid;Fmoc-D-Pip-OH;fmoc-d-hopro-oh;(r)-1-(((9h-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid;fmoc-d-piperidine-2-carboxylic acid;(R)-N-Fmoc-piperidine-2-carboxylic acid;fmoc-d-homopro-oh;(d)-n-fmoc-pipecolic acid;D-1-Fmoc-Pipecolinic acid;(2R)-1-(9H-fluoren-9-ylmethoxycarbonyl)piperidine-2-carboxylic acid;fmoc-(r)-(+)-piperidine-2-carboxylic acid;N-Fmoc-D-pipecolic acid;MFCD00235899;(2r)-1-[(9h-fluoren-9-ylmethoxy)carbonyl]hexahydropyridine-2-carboxylic acid;Fmoc-D-pipecolic acid;D-Fmoc-pipecolic acid;n-fmoc-d-pipecolinic acid;1-Fmoc-D-pipecolic Acid;n-fmoc-(r)-pipecolinic acid;Oprea1_652245;AO-710/25079003;SCHEMBL119365;DTXSID901314811;Fmoc-D-Pip-OH, >=98.0%;(2r)-1-[(9h-fluoren-9-ylmethoxy)carbonyl]piperidine-2-carboxylic acid;AKOS015837390;CCG-256525;CS-W011864;(R)-1-Fmoc-2-piperidinecarboxylic Acid;AC-24145;AS-15971;F0937;(R)-N-Fmoc-piperidine-2-carboxylic acid, 97%;EN300-1556223;A800406;(r)-piperidine-2-carboxylic acid, n-fmoc protected;J-000432;1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-pipecolic Acid;(r)-n-(9-fluorenylmethyloxycarbonyl)-piperidine-2-carboxylic acid;1-[(9H-fluoren-9-ylmethoxy)carbonyl]piperidine-2-carboxylic acid;2-[9H-fluoren-9-ylmethoxy(oxo)methyl]-2-piperidinecarboxylic acid;(R)-1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-piperidinecarboxylic Acid;(r)-piperidine-1,2-dicarboxylic acid 1-(9h-fluoren-9-ylmethyl) ester;(2R)-1-{[(9H-FLUOREN-9-YL)METHOXY]CARBONYL}PIPERIDINE-2-CARBOXYLIC ACID

Chemical Property of (r)-1-(((9h-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

Chemical Property:

• Vapor Pressure: 1.89E-13mmHg at 25°C
• Melting Point: 150-151℃
• Refractive Index: 1.62
• Boiling Point: 561.6 °C at 760 mmHg
• Flash Point: 293.5 °C
• PSA: 66.84000
• Density: 1.293 g/cm³
• LogP: 3.81250
• Storage Temp.: 2-8°C
• XLogP3: 3.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 351.14705815
• Heavy Atom Count: 26
• Complexity: 514

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-Fmoc-piperidine-2-carboxylic acid 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,N
• Statements: 36/37/38-50/53
• Safety Statements: 26-36-61-60

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCN(C(C1)C(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
• Isomeric SMILES: C1CCN([C@H](C1)C(=O)O)C(=O)OCC2C3=CC=CC=C3C4=CC=CC=C24
• Uses: Reactant for racemic solid-phase preparation of human protease activated receptor 2 agonists and antagonistsAnalyte for urea-linked cinchona-calexarene hybrid type receptors for chromatographic enantiomer separation of carbamate-protected amino acidsCombinatorial reactant for assembly of alkylglycine library arrays by SPOT technique on cellulose membranes for identification of micromolar ligands for monoclonal antibodies

Technology Process of (r)-1-(((9h-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid

There total 18 articles about (r)-1-(((9h-Fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

N-(9H-fluoren-2-ylmethoxycarbonyloxy)succinimide (82911-69-1) + (R)-(+)-pipecolic acid (1723-00-8,83680-83-5) → (R)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (101555-63-9,86069-86-5,105751-19-7)

Guidance literature:

With sodium carbonate; In 1,4-dioxane; water; at 20 ℃;

Reference yield: 83.0%

pipecolinic acid (3105-95-1,83680-83-5) → (S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (101555-63-9,105751-19-7,86069-86-5)

Guidance literature:

pipecolinic acid; With sodium carbonate; at 20 ℃; for 0.0833333h;

F-moc succinamide; In 1,4-dioxane;

With hydrogenchloride; In water; pH=2;

Reference yield: 83.0%

9-fluorenylmethyl N-succinimidyl carbonate (102774-86-7) + pipecolinic acid (3105-95-1,83680-83-5) → (S)-1-(((9H-fluoren-9-yl)methoxy)carbonyl)piperidine-2-carboxylic acid (101555-63-9,105751-19-7,86069-86-5)

Guidance literature:

With potassium carbonate; In 1,4-dioxane; at 20 ℃;

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

(2S)-2-piperidinecarboxylic acid L-tartrate

(9-fluorenyl)methyl pentafluorophenyl carbonate

pipecolinic acid

Downstream raw materials:

C₃₄H₃₇NO₆

(R)-N-(9-fluorenylmethoxycarbonyl)-(S)-pipecolinylphenyllactic acid

1-((9H-fluoren-9-yl)methyl) 2-((R)-3-(3,4-dimethoxyphenyl)-1-(3-(2-morpholinoethoxy)phenyl)propyl) (S)-piperidine-1,2-dicarboxylate

C₄₃H₄₇NO₁₀

Refernces

• 1、 -. "2-ARYLSULFONAMIDO-N-ARYLACETAMIDE DERIVATIZED STAT3 INHIBITORS". Paragraph 00342. . Retrieved 2018/08/20.
• 2、 -. "THROMBIN INHIBITORS". Page/Page column 23. . Retrieved 2013/10/21.