N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2-aminoacetamide

Base Information

Chemical Name:N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2-aminoacetamide
CAS No.:1607465-01-9
Molecular Formula:C₁₈H₂₂N₄O₄S
Molecular Weight:390.463
Hs Code.:

Synonyms:N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2-aminoacetamide

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Chemical Property of N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2-aminoacetamide

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Technology Process of N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2-aminoacetamide

There total 4 articles about N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2-aminoacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 32.0%

: 4530-20-5
BOC-glycine

: 134812-30-9
N-(4-(3'-aminophenyl)thiazol-2-yl)acetamide

: 1607465-01-9
N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2-aminoacetamide

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; for 3h; Reflux;
DOI:10.1002/chem.201303664

Reference yield:

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 1607465-01-9
N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2-aminoacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: ethanol / 0.5 h / Reflux

2: 5%-palladium/activated carbon; sodium tetrahydroborate; isopropyl alcohol / 3 h / 20 °C

3: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 3 h / 20 °C

With sodium tetrahydroborate; 5%-palladium/activated carbon; dicyclohexyl-carbodiimide; isopropyl alcohol; In ethanol; N,N-dimethyl-formamide;

Reference yield:

: 121-89-1
3-Nitroacetophenone

: 1607465-01-9
N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2-aminoacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: aluminum (III) chloride; bromine / diethyl ether / 1 h / 20 °C / Cooling with ice

2: ethanol / 0.5 h / Reflux

3: 5%-palladium/activated carbon; sodium tetrahydroborate; isopropyl alcohol / 3 h / 20 °C

4: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 3 h / 20 °C

With aluminum (III) chloride; sodium tetrahydroborate; 5%-palladium/activated carbon; bromine; dicyclohexyl-carbodiimide; isopropyl alcohol; In diethyl ether; ethanol; N,N-dimethyl-formamide;