Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2-aminoacetamide]histidinamide

Base Information

Chemical Name:Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2-aminoacetamide]histidinamide
CAS No.:1607465-10-0
Molecular Formula:C₂₉H₃₇N₇O₇S
Molecular Weight:627.721
Hs Code.:

Synonyms:Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2-aminoacetamide]histidinamide

Suppliers and Price of Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2-aminoacetamide]histidinamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2-aminoacetamide]histidinamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2-aminoacetamide]histidinamide

There total 3 articles about Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2-aminoacetamide]histidinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

: 1607465-05-3
N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2-aminoacetamide trifluoroacetate

: 20866-46-0
N,1'-bis[(1,1-dimethylethoxy)carbonyl]-L-histidine

: 1607465-10-0
Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2-aminoacetamide]histidinamide

Guidance literature:: With dmap; benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h; Inert atmosphere;
DOI:10.1002/chem.201303664

Reference yield:

: 1607465-01-9
N-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)]-2-aminoacetamide

: 1607465-10-0
Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2-aminoacetamide]histidinamide

Guidance literature:: Multi-step reaction with 2 steps

1: dichloromethane / 24 h / 20 °C

2: triethylamine; benzotriazol-1-ol; diisopropyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C / Inert atmosphere

With dmap; benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide; In dichloromethane;
DOI:10.1002/chem.201303664

Reference yield:

: 134812-30-9
N-(4-(3'-aminophenyl)thiazol-2-yl)acetamide

: 1607465-10-0
Nα,Nδ-di-tert-butoxycarbonyl[N-(2-N-acetylamino-4-(3-aminophenyl)thiazole)-2-aminoacetamide]histidinamide

Guidance literature:: Multi-step reaction with 3 steps

1: 2-chloro-1-methyl-pyridinium iodide; triethylamine / dichloromethane / 3 h / Reflux

2: dichloromethane / 24 h / 20 °C

3: triethylamine; benzotriazol-1-ol; diisopropyl-carbodiimide; dmap / dichloromethane / 24 h / 20 °C / Inert atmosphere

With dmap; 2-chloro-1-methyl-pyridinium iodide; benzotriazol-1-ol; triethylamine; diisopropyl-carbodiimide; In dichloromethane;
DOI:10.1002/chem.201303664