cis phenylmethyl-4-[4-(4-fluorophenyl)-4-hydroxycyclohexyl]-1-piperazine carboxylate

Base Information

Chemical Name:cis phenylmethyl-4-[4-(4-fluorophenyl)-4-hydroxycyclohexyl]-1-piperazine carboxylate
CAS No.:151983-08-3
Molecular Formula:C₂₄H₂₉FN₂O₃
Molecular Weight:412.504
Hs Code.:

Synonyms:cis phenylmethyl-4-[4-(4-fluorophenyl)-4-hydroxycyclohexyl]-1-piperazine carboxylate

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Chemical Property of cis phenylmethyl-4-[4-(4-fluorophenyl)-4-hydroxycyclohexyl]-1-piperazine carboxylate

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Technology Process of cis phenylmethyl-4-[4-(4-fluorophenyl)-4-hydroxycyclohexyl]-1-piperazine carboxylate

There total 5 articles about cis phenylmethyl-4-[4-(4-fluorophenyl)-4-hydroxycyclohexyl]-1-piperazine carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

: 546-68-9
titanium(IV) isopropylate

: 31166-44-6
phenylmethyl 1-piperazinecarboxylate

: 36716-69-5
4-(4-fluorophenyl)-4-hydroxycyclohexanone

: 151983-08-3
cis phenylmethyl-4-[4-(4-fluorophenyl)-4-hydroxycyclohexyl]-1-piperazine carboxylate

Guidance literature:: With sodium borohydrid; In ethanol; water;

Reference yield:

: 31166-44-6
phenylmethyl 1-piperazinecarboxylate

: 36716-69-5
4-(4-fluorophenyl)-4-hydroxycyclohexanone

: 151983-08-3
cis phenylmethyl-4-[4-(4-fluorophenyl)-4-hydroxycyclohexyl]-1-piperazine carboxylate

Guidance literature:: With titanium(IV) isopropylate; sodium tetrahydroborate;
DOI:10.1016/S0960-894X(02)00879-X

Reference yield:

: 4746-97-8
cyclohexanedione monoethylene ketal

: 151983-08-3
cis phenylmethyl-4-[4-(4-fluorophenyl)-4-hydroxycyclohexyl]-1-piperazine carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrahydrofuran

2: aq. HCl

3: NaBH₄; Ti(OiPr)4

With titanium(IV) isopropylate; hydrogenchloride; sodium tetrahydroborate; In tetrahydrofuran;
DOI:10.1016/S0960-894X(02)00879-X