phenylmethyl 4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoate

Base Information

Chemical Name:phenylmethyl 4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoate
CAS No.:1362820-86-7
Molecular Formula:C₂₇H₂₄F₃NO₅
Molecular Weight:499.486
Hs Code.:

Synonyms:phenylmethyl 4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoate

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Chemical Property of phenylmethyl 4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoate

Chemical Property:

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Technology Process of phenylmethyl 4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoate

There total 11 articles about phenylmethyl 4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 110-91-8,99108-56-2
morpholine

: 1362820-83-4
5-[(phenylmethyl)oxy]-4-{[(phenylmethyl)oxy]carbonyl}-2-(trifluoromethyl)benzoic acid

: 1362820-86-7
phenylmethyl 4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoate

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 18h;

Reference yield:

: 81245-24-1
methyl 4-methyl-2-methoxybenzoate

: 1362820-86-7
phenylmethyl 4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 9 steps

1: bromine / chloroform / 1.08 h / 0 °C

2: copper(l) iodide / N,N-dimethyl-formamide; toluene / 18.75 h / 170 °C

3: boron tribromide / dichloromethane / 2 h / 0 °C

4: pyridine / 2 h

5: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / 85 °C

6: water; calcium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

7: caesium carbonate / N,N-dimethyl-formamide / 19 h / 60 °C

8: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 1 h / 0 °C

9: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C

With pyridine; sodium chlorite; N-Bromosuccinimide; copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; aminosulfonic acid; water; bromine; boron tribromide; caesium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; calcium carbonate; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;

Reference yield:

: 50-85-1
2-hydroxy-p-toluic acid

: 1362820-86-7
phenylmethyl 4-(4-morpholinylcarbonyl)-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoate

Guidance literature:: Multi-step reaction with 10 steps

1: potassium carbonate / acetone / 5 h / 50 °C

2: bromine / chloroform / 1.08 h / 0 °C

3: copper(l) iodide / N,N-dimethyl-formamide; toluene / 18.75 h / 170 °C

4: boron tribromide / dichloromethane / 2 h / 0 °C

5: pyridine / 2 h

6: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / 85 °C

7: water; calcium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation

8: caesium carbonate / N,N-dimethyl-formamide / 19 h / 60 °C

9: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 1 h / 0 °C

10: 1-hydroxy-7-aza-benzotriazole; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 18 h / 20 °C

With pyridine; sodium chlorite; N-Bromosuccinimide; copper(l) iodide; 1-hydroxy-7-aza-benzotriazole; aminosulfonic acid; water; bromine; boron tribromide; potassium carbonate; caesium carbonate; 2-Methyl-1-butene; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; calcium carbonate; dibenzoyl peroxide; In tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene;