Technology Process of 5-[(phenylmethyl)oxy]-4-{[(phenylmethyl)oxy]carbonyl}-2-(trifluoromethyl)benzoic acid
There total 10 articles about 5-[(phenylmethyl)oxy]-4-{[(phenylmethyl)oxy]carbonyl}-2-(trifluoromethyl)benzoic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium chlorite; aminosulfonic acid; 2-Methyl-1-butene;
In
tetrahydrofuran; water; dimethyl sulfoxide;
at 0 ℃;
for 1h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1: bromine / chloroform / 1.08 h / 0 °C
2: copper(l) iodide / N,N-dimethyl-formamide; toluene / 18.75 h / 170 °C
3: boron tribromide / dichloromethane / 2 h / 0 °C
4: pyridine / 2 h
5: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / 85 °C
6: water; calcium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation
7: caesium carbonate / N,N-dimethyl-formamide / 19 h / 60 °C
8: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 1 h / 0 °C
With
pyridine; sodium chlorite; N-Bromosuccinimide; copper(l) iodide; aminosulfonic acid; water; bromine; boron tribromide; caesium carbonate; 2-Methyl-1-butene; calcium carbonate;
dibenzoyl peroxide;
In
tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 9 steps
1: potassium carbonate / acetone / 5 h / 50 °C
2: bromine / chloroform / 1.08 h / 0 °C
3: copper(l) iodide / N,N-dimethyl-formamide; toluene / 18.75 h / 170 °C
4: boron tribromide / dichloromethane / 2 h / 0 °C
5: pyridine / 2 h
6: N-Bromosuccinimide / dibenzoyl peroxide / tetrachloromethane / 18 h / 85 °C
7: water; calcium carbonate / 1,4-dioxane / 4 h / 150 °C / Microwave irradiation
8: caesium carbonate / N,N-dimethyl-formamide / 19 h / 60 °C
9: 2-Methyl-1-butene; aminosulfonic acid; sodium chlorite / water; dimethyl sulfoxide; tetrahydrofuran / 1 h / 0 °C
With
pyridine; sodium chlorite; N-Bromosuccinimide; copper(l) iodide; aminosulfonic acid; water; bromine; boron tribromide; potassium carbonate; caesium carbonate; 2-Methyl-1-butene; calcium carbonate;
dibenzoyl peroxide;
In
tetrahydrofuran; 1,4-dioxane; tetrachloromethane; dichloromethane; chloroform; water; dimethyl sulfoxide; N,N-dimethyl-formamide; acetone; toluene;
![phenylmethyl 4-formyl-2-[(phenylmethyl)oxy]-5-(trifluoromethyl)benzoate](/Databaselist/images/loading.webp)
