3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID

Base Information

• Chemical Name: 3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID
• CAS No.: 179024-65-8
• Molecular Formula: C11H14N2O4
• Molecular Weight: 238.243
• Hs Code.: 29333990
• Mol file: 179024-65-8.mol

Synonyms:3-(tert-Butoxycarbonylamino)pyridine-4-carboxylicacid;3-[N-(tert-Butoxycarbonyl)amino]isonicotinic acid;3-tert-Butoxycarbonylamino-isonicotinic acid;

Chemical Property of 3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID

Chemical Property:

• Vapor Pressure: 4.27E-07mmHg at 25°C
• Melting Point: 280°(dec)
• Refractive Index: 1.578
• Boiling Point: 399.4 °C at 760 mmHg
• Flash Point: 195.3 °C
• PSA: 88.52000
• Density: 1.293 g/cm³
• LogP: 2.19980
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

3-((tert-Butoxycarbonyl)amino)isonicotinicAcid ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID

There total 4 articles about 3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

carbon dioxide (124-38-9,18923-20-1) + 3-(tert-butoxycarbonylamino)pyridine (56700-70-0) → 3-tert-butoxycarbonylaminoisonicotinic acid (179024-65-8)

Guidance literature:

3-(tert-butoxycarbonylamino)pyridine; With n-butyllithium; In tetrahydrofuran; hexane; at -60 - 0 ℃; for 0.25h; Cooling with acetone-dry ice;

carbon dioxide; In tetrahydrofuran; hexane; at 20 ℃; for 2h; Cooling with acetone-dry ice;

Reference yield:

nicotinic acid (59-67-6) → 3-tert-butoxycarbonylaminoisonicotinic acid (179024-65-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: N-ethyl-N,N-diisopropylamine; diphenyl phosphoryl azide / toluene / 0.5 h / 20 °C

1.2: 6 h / 80 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / -60 - 0 °C

2.2: 2 h / 20 °C / Cooling with acetone-dry ice

2.3: pH ~ 3

With n-butyllithium; diphenyl phosphoryl azide; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; hexane; toluene;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 3-Aminopyridine-4-carboxylic acid (7579-20-6) → 3-tert-butoxycarbonylaminoisonicotinic acid (179024-65-8)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jm000315p

upstream raw materials:

di-tert-butyl dicarbonate

3-Aminopyridine-4-carboxylic acid

carbon dioxide

3-(tert-butoxycarbonylamino)pyridine

Downstream raw materials:

(3R)-3-t-Butyloxycarbonylamino-N-(9-amino-4-oxo-1-phenyl-3,4,6,7-tetrahydro [1,4 ]diazepino [6,7,1-hi]indol-3-yl) isonicotinamide

3-Aminopyridine-4-carboxylic acid

C₃₉H₅₅N₅O₈

2,6-dichloro-3-amino-4-pyridinecarboxylic acid methyl ester

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 179024-65-8 3-TERT-BUTOXYCARBONYLAMINO-ISONICOTINIC ACID

Send

Send

Metric Ton KG G Pound L ML

Send

Send