N-3-{N',N'-bis[(6'-bromo-2,2'-bipyridine-6-yl)methyl]aminopropyl}-4-nitrobenzamide

Base Information

• Chemical Name: N-3-{N',N'-bis[(6'-bromo-2,2'-bipyridine-6-yl)methyl]aminopropyl}-4-nitrobenzamide
• CAS No.: 656259-11-9
• Molecular Formula: C₃₂H₂₇Br₂N₇O₃
• Molecular Weight: 717.419
• Mol file: 656259-11-9.mol

Synonyms:N-3-{N',N'-bis[(6'-bromo-2,2'-bipyridine-6-yl)methyl]aminopropyl}-4-nitrobenzamide

Chemical Property of N-3-{N',N'-bis[(6'-bromo-2,2'-bipyridine-6-yl)methyl]aminopropyl}-4-nitrobenzamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-3-{N',N'-bis[(6'-bromo-2,2'-bipyridine-6-yl)methyl]aminopropyl}-4-nitrobenzamide

There total 2 articles about N-3-{N',N'-bis[(6'-bromo-2,2'-bipyridine-6-yl)methyl]aminopropyl}-4-nitrobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

N-(3-aminopropyl)-4-nitrobenzamide (88342-18-1) + 6-bromo-6'-bromomethyl-2,2'-bipyridine (656258-97-8) → N-3-{N',N'-bis[(6'-bromo-2,2'-bipyridine-6-yl)methyl]aminopropyl}-4-nitrobenzamide (656259-11-9)

Guidance literature:

With potassium carbonate; In acetonitrile; at 85 ℃; for 22h;

DOI:10.1055/s-2003-42449

Reference yield:

6-bromo-6′-methyl-2,2′-bipyridine (130897-00-6) → N-3-{N',N'-bis[(6'-bromo-2,2'-bipyridine-6-yl)methyl]aminopropyl}-4-nitrobenzamide (656259-11-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 48 percent / AIBN; NBS / benzene / 2.5 h / Heating; irradiation

2: 70 percent / K₂CO₃ / acetonitrile / 22 h / 85 °C

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); potassium carbonate; In acetonitrile; benzene;

DOI:10.1055/s-2003-42449

Reference yield: 65.0%

ethanol (64-17-5) + carbon monoxide (201230-82-2) + N-3-{N',N'-bis[(6'-bromo-2,2'-bipyridine-6-yl)methyl]aminopropyl}-4-nitrobenzamide (656259-11-9) → N-3-{N',N'-bis[(6'-carboethoxy-2,2'-bipyridine-6-yl)methyl]aminopropyl}-4-nitrobenzamide (656259-13-1)

Guidance literature:

With triethylamine; bis-triphenylphosphine-palladium(II) chloride; at 70 ℃;

DOI:10.1055/s-2003-42449

upstream raw materials:

N-(3-aminopropyl)-4-nitrobenzamide

6-bromo-6'-bromomethyl-2,2'-bipyridine

6-bromo-6′-methyl-2,2′-bipyridine

Downstream raw materials:

N-3-{N',N'-bis[(6'-carboethoxy-2,2'-bipyridine-6-yl)methyl]aminopropyl}-4-nitrobenzamide