C₁₉H₂₆O₃

Base Information

• Chemical Name: C₁₉H₂₆O₃
• CAS No.: 1338951-77-1
• Molecular Formula: C₁₉H₂₆O₃
• Molecular Weight: 302.414
• Mol file: 1338951-77-1.mol

Synonyms:C₁₉H₂₆O₃

Chemical Property of C₁₉H₂₆O₃

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₁₉H₂₆O₃

There total 3 articles about C₁₉H₂₆O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

(1S,2S,6R)-1-[2-(3-isopropyl-2-methoxyphenyl)ethyl]-6-methyl-7-oxabicyclo[4.1.0]heptan-2-ol (1338951-76-0) → C19H26O3 (1338951-77-1)

Guidance literature:

With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1016/j.tet.2011.08.050

Reference yield:

2-[2-(3-isopropyl-2-methoxyphenyl)ethyl]-3-methylcyclohex-2-en-1-one (1245920-23-3) → C19H26O3 (1338951-77-1)

Guidance literature:

Multi-step reaction with 3 steps

1: dimethylsulfide borane complex; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

3: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere

With dimethylsulfide borane complex; sodium hydrogencarbonate; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; (3aR)-1-methyl-3,3-diphenyl-tetrahydro-pyrrolo[1,2-c][1,3,2]oxazaborole; In tetrahydrofuran; dichloromethane; 3: Dess-Martin oxidation;

DOI:10.1016/j.tet.2011.08.050

Reference yield:

(1S)-2-[2-(3-isopropyl-2-methoxyphenyl)ethyl]-3-methylcyclohex-2-en-1-ol (1338951-75-9) → C19H26O3 (1338951-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid / dichloromethane / 1 h / 0 °C / Inert atmosphere

2: Dess-Martin periodane / dichloromethane / 2 h / 20 °C / Inert atmosphere

With sodium hydrogencarbonate; Dess-Martin periodane; 3-chloro-benzenecarboperoxoic acid; In dichloromethane; 2: Dess-Martin oxidation;

DOI:10.1016/j.tet.2011.08.050

upstream raw materials:

2-[2-(3-isopropyl-2-methoxyphenyl)ethyl]-3-methylcyclohex-2-en-1-one

(1S)-2-[2-(3-isopropyl-2-methoxyphenyl)ethyl]-3-methylcyclohex-2-en-1-ol

(1S,2S,6R)-1-[2-(3-isopropyl-2-methoxyphenyl)ethyl]-6-methyl-7-oxabicyclo[4.1.0]heptan-2-ol