(R)-3-(5-bromo-2-fluorophenyl)-1-methoxy-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine

Base Information

Chemical Name:(R)-3-(5-bromo-2-fluorophenyl)-1-methoxy-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine
CAS No.:1398113-21-7
Molecular Formula:C₁₅H₁₄BrFN₂O
Molecular Weight:337.191
Hs Code.:

Synonyms:(R)-3-(5-bromo-2-fluorophenyl)-1-methoxy-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine

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Chemical Property of (R)-3-(5-bromo-2-fluorophenyl)-1-methoxy-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine

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Technology Process of (R)-3-(5-bromo-2-fluorophenyl)-1-methoxy-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine

There total 11 articles about (R)-3-(5-bromo-2-fluorophenyl)-1-methoxy-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1398113-20-6
(R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one

: 420-37-1
trimethoxonium tetrafluoroborate

: 1398113-21-7
(R)-3-(5-bromo-2-fluorophenyl)-1-methoxy-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine

Guidance literature:: (R)-3-(5-bromo-2-fluorophenyl)-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one; trimethoxonium tetrafluoroborate; In dichloromethane; at 20 ℃; for 96h;

With sodium hydrogencarbonate; In water;

Reference yield:

: 1228571-14-9
(2R)-2-amino-2-(5-bromo-2-fluorophenyl)propan-1-ol

: 1398113-21-7
(R)-3-(5-bromo-2-fluorophenyl)-1-methoxy-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 0 - 20 °C

2.1: thionyl chloride / acetonitrile / 0.5 h / -40 °C / Inert atmosphere

2.2: 64 h / -40 - 20 °C / Inert atmosphere

3.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 2 h / 0 - 20 °C

4.1: caesium carbonate / acetonitrile / 0.5 h / 130 °C / Microwave irradiation

5.1: hydrogenchloride / 1,4-dioxane / 20 °C

6.1: sodium methylate / methanol / 60 °C

7.1: dichloromethane / 96 h / 20 °C

With hydrogenchloride; ruthenium trichloride; sodium periodate; thionyl chloride; sodium methylate; sodium hydrogencarbonate; caesium carbonate; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00181

Reference yield:

: 1383742-04-8
tert-butyl N-[(1R)-1-(5-bromo-2-fluorophenyl)-2-hydroxy-1-methylethyl]carbamate

: 1398113-21-7
(R)-3-(5-bromo-2-fluorophenyl)-1-methoxy-3-methyl-3,4-dihydropyrrolo[1,2-a]pyrazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / acetonitrile / 0.5 h / -40 °C / Inert atmosphere

1.2: 64 h / -40 - 20 °C / Inert atmosphere

2.1: ruthenium trichloride; sodium periodate / water; acetonitrile / 2 h / 0 - 20 °C

3.1: caesium carbonate / acetonitrile / 0.5 h / 130 °C / Microwave irradiation

4.1: hydrogenchloride / 1,4-dioxane / 20 °C

5.1: sodium methylate / methanol / 60 °C

6.1: dichloromethane / 96 h / 20 °C

With hydrogenchloride; ruthenium trichloride; sodium periodate; thionyl chloride; sodium methylate; caesium carbonate; In 1,4-dioxane; methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/acsmedchemlett.9b00181