2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

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Chemical Name:2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one
CAS No.:1448869-74-6
Molecular Formula:C₂₂H₂₀BrCl₂N₃O
Molecular Weight:493.23
Hs Code.:

Synonyms:2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

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Chemical Property of 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

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Technology Process of 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

There total 6 articles about 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1448869-75-7
2-bromo-5-((4-chloro-2-methylphenyl)(5-chloro-2-methylphenylamino)methyl)-1-isopropyl-1H-imidazole-4-carboxylic acid

: 1448869-74-6
2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

Guidance literature:: With 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2018.08.027

Reference yield:

: 1260793-84-7
1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

: 1448869-74-6
2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

Guidance literature:: Multi-step reaction with 6 steps

1: N-Bromosuccinimide / tetrahydrofuran / 20 °C

2: lithium diisopropyl amide / tetrahydrofuran

3: Methanesulfonic anhydride; triethylamine / tetrahydrofuran; dichloromethane / 0.25 h / 5 °C

4: 2.75 h / 25 °C

5: sodium hydroxide / tetrahydrofuran; water; methanol / 25 °C

6: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide; dichloromethane

With 4-methyl-morpholine; N-Bromosuccinimide; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; lithium diisopropyl amide; Methanesulfonic anhydride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2018.08.027

Reference yield:

: 1448869-67-7
2-bromo-1-isopropyl-1H-imidazole-4-carboxylic acid ethyl ester

: 1448869-74-6
2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazole-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: lithium diisopropyl amide / tetrahydrofuran

2: Methanesulfonic anhydride; triethylamine / tetrahydrofuran; dichloromethane / 0.25 h / 5 °C

3: 2.75 h / 25 °C

4: sodium hydroxide / tetrahydrofuran; water; methanol / 25 °C

5: 4-methyl-morpholine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide; dichloromethane

With 4-methyl-morpholine; triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; lithium diisopropyl amide; Methanesulfonic anhydride; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2018.08.027