4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Base Information

• Chemical Name: 4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• CAS No.: 288851-44-5
• Molecular Formula: C13H22 N2 O5
• Molecular Weight: 286.32
• Hs Code.: 2933599090
• Mol file: 288851-44-5.mol

Synonyms:BUTTPARK 82\11-12;1-BOC-4-(3-CARBOXY-PROPIONYL)-PIPERAZINE;4-[4-(TERT-BUTOXYCARBONYL)PIPERAZIN-1-YL]-4-OXOBUTANOIC ACID;4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;4-(3-Carboxy-propionyl)-piperazine-1-carboxylic

Chemical Property of 4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Chemical Property:

• Vapor Pressure: 2.82E-10mmHg at 25°C
• Melting Point: 127-129°C
• Boiling Point: 473.6°Cat760mmHg
• Flash Point: 240.2°C
• PSA: 87.15000
• Density: 1.22g/cm³
• LogP: 0.80630
• Storage Temp.: 2-8°C

Purity/Quality:

99.0%Min ^*data from raw suppliers

4-(3-Carboxy-propionyl)-piperazine-1-carboxylicAcidtert-ButylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

There total 2 articles about 4-(3-CARBOXY-PROPIONYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

succinic acid anhydride (108-30-5) + 1-t-Butoxycarbonylpiperazine (57260-71-6) → 4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoic acid (288851-44-5)

Guidance literature:

In chloroform; for 0.333333h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 4-oxo-4-piperazin-1-yl-butyric acid (72547-43-4) → 4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoic acid (288851-44-5)

Guidance literature:

With sodium hydroxide; Yield given;

DOI:10.1016/S0040-4039(97)00973-8

Reference yield: 84.0%

2,3,4,5,6-pentafluorophenol (771-61-9) + 4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoic acid (288851-44-5) → pentafluorophenyl 4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoate (329911-76-4)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 0.666667h;

upstream raw materials:

di-tert-butyl dicarbonate

4-oxo-4-piperazin-1-yl-butyric acid

succinic acid anhydride

1-t-Butoxycarbonylpiperazine

Downstream raw materials:

pentafluorophenyl 4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoate

m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]-benzoic acid

succinimidyl m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoate

m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoyl-β-(3,4-methylenedioxyphenyl)-β-alanine

Refernces

• 1、 -. "METHODS, MIXTURES, KITS AND COMPOSITIONS PERTAINING TO ANALYTE DETERMINATION". Page/Page column 79. . Retrieved 2010/11/28.
• 2、 Andronati,Krysko,Kabanov,Karaseva,Kabanova. "Synthesis and properties of peptidomimetics - Inhibitors of platelet aggregation". . p. 15 - 21. Retrieved 2007/10/03.