succinimidyl m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoate

Base Information

• Chemical Name: succinimidyl m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoate
• CAS No.: 858555-36-9
• Molecular Formula: C₂₄H₃₀N₄O₈
• Molecular Weight: 502.524
• Mol file: 858555-36-9.mol

Synonyms:succinimidyl m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoate

Chemical Property of succinimidyl m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of succinimidyl m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoate

There total 6 articles about succinimidyl m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]-benzoic acid (858555-32-5) + 1-hydroxy-pyrrolidine-2,5-dione (6066-82-6) → succinimidyl m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoate (858555-36-9)

Guidance literature:

With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 0 ℃; for 4h;

DOI:10.1023/B:RUBI.0000049769.62906.0d

Reference yield:

4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoic acid (288851-44-5) → succinimidyl m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoate (858555-36-9)

Guidance literature:

Multi-step reaction with 3 steps

1: triethylamine

2: 0.76 g / triethylamine / CHCl₃ / 3 h / Heating

3: 80 percent / DCC / tetrahydrofuran / 4 h / 0 °C

With triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform;

DOI:10.1023/B:RUBI.0000049769.62906.0d

Reference yield:

4-(4-isobutoxycarbonyloxy-4-oxo-butyryl)-piperazine-1-carboxylic acid tert-butyl ester → succinimidyl m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoate (858555-36-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 0.76 g / triethylamine / CHCl₃ / 3 h / Heating

2: 80 percent / DCC / tetrahydrofuran / 4 h / 0 °C

With triethylamine; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform;

DOI:10.1023/B:RUBI.0000049769.62906.0d

upstream raw materials:

m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]-benzoic acid

1-hydroxy-pyrrolidine-2,5-dione

meta-aminobenzoic acid

4-(4-tert-butoxycarbonyl-piperazin-1-yl)-4-oxobutanoic acid

Downstream raw materials:

m-[4-oxo-4-(4-Boc-piperazin-1-yl)butyrylamino]benzoyl-β-(3,4-methylenedioxyphenyl)-β-alanine