(4R,5S,2'R,3'R)-1,5-dimethyl-4-phenyl-3-(3'-hydroxy-2'-methyl-3'-phenylpropanoyl)imidazolidin-2-one

Base Information

Chemical Name:(4R,5S,2'R,3'R)-1,5-dimethyl-4-phenyl-3-(3'-hydroxy-2'-methyl-3'-phenylpropanoyl)imidazolidin-2-one
CAS No.:136630-05-2
Molecular Formula:C₂₁H₂₄N₂O₃
Molecular Weight:352.433
Hs Code.:

Synonyms:(4R,5S,2'R,3'R)-1,5-dimethyl-4-phenyl-3-(3'-hydroxy-2'-methyl-3'-phenylpropanoyl)imidazolidin-2-one

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Chemical Property of (4R,5S,2'R,3'R)-1,5-dimethyl-4-phenyl-3-(3'-hydroxy-2'-methyl-3'-phenylpropanoyl)imidazolidin-2-one

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Technology Process of (4R,5S,2'R,3'R)-1,5-dimethyl-4-phenyl-3-(3'-hydroxy-2'-methyl-3'-phenylpropanoyl)imidazolidin-2-one

There total 3 articles about (4R,5S,2'R,3'R)-1,5-dimethyl-4-phenyl-3-(3'-hydroxy-2'-methyl-3'-phenylpropanoyl)imidazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-52-7
benzaldehyde

: 112712-55-7
deux références XF130 et XF154

: 136630-05-2
(4R,5S,2'R,3'R)-1,5-dimethyl-4-phenyl-3-(3'-hydroxy-2'-methyl-3'-phenylpropanoyl)imidazolidin-2-one

Guidance literature:: With di-n-butylboryl trifluoromethanesulfonate; triethylamine; Yield given. Multistep reaction; 1) CH₂Cl₂, -10 deg C, 1h, 2a) -78 deg C, 30 min, 2b) 0 deg C, 1h;

Reference yield:

: 92841-65-1
(4R,5S)-1,5-dimethyl-4-phenylimidazolidin-2-one

: 136630-05-2
(4R,5S,2'R,3'R)-1,5-dimethyl-4-phenyl-3-(3'-hydroxy-2'-methyl-3'-phenylpropanoyl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C, 1 h

2: 1.) 1M n-Bu₂BOSO₂CF₃, Et₃N / 1.) CH₂Cl₂, -10 deg C, 1 h, 2.) CH₂Cl₂, -78 deg C, 30 min; -10 deg C, 1 h

With n-butyllithium; di-n-butylboryl trifluoromethanesulfonate; triethylamine;

Reference yield:

: 50-98-6
ephedrine hydrochloride

: 136630-05-2
(4R,5S,2'R,3'R)-1,5-dimethyl-4-phenyl-3-(3'-hydroxy-2'-methyl-3'-phenylpropanoyl)imidazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 60 percent / 1.) 170 - 175 deg C, 30 min, 2.) 200 - 210 deg C, 1 h

2: 1.) n-BuLi / 1.) THF, 0 deg C, 30 min, 2.) THF, 0 deg C, 1 h

3: 1.) 1M n-Bu₂BOSO₂CF₃, Et₃N / 1.) CH₂Cl₂, -10 deg C, 1 h, 2.) CH₂Cl₂, -78 deg C, 30 min; -10 deg C, 1 h

With n-butyllithium; di-n-butylboryl trifluoromethanesulfonate; triethylamine;