5-<2-(methylthio)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole

Base Information

Chemical Name:5-<2-(methylthio)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole
CAS No.:200801-91-8
Molecular Formula:C₂₈H₂₆F₃N₅O₂S
Molecular Weight:553.608
Hs Code.:

Synonyms:5-<2-(methylthio)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole

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Chemical Property of 5-<2-(methylthio)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole

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Technology Process of 5-<2-(methylthio)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole

There total 6 articles about 5-<2-(methylthio)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 200801-90-7
4-[1-hydroxy-5-(2-methylthiopyrimidin-4-yl)-4-(3-trifluoromethylphenyl)-1H-imidazol-2-yl]piperidine-1-carboxylic acid benzyl ester

: 200801-91-8
5-<2-(methylthio)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole

Guidance literature:: With hydrogenchloride; titanium(III) chloride; In methanol; at 20 ℃; for 3h; Yield given;
DOI:10.1021/jm9805236

Reference yield:

: 14001-63-9
2-methylthio-4-methylpyrimidine

: 200801-91-8
5-<2-(methylthio)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 5 min

2: 100 percent / aq. NaNO₂, HOAc / 1 h / 5 - 20 °C

3: 97 percent / ammonium acetate, AcOH / 2 h / Heating

4: TiCl₃, aq. HCl / methanol / 3 h / 20 °C

With ammonium acetate; hydrogenchloride; titanium(III) chloride; acetic acid; lithium diisopropyl amide; sodium nitrite; In methanol;
DOI:10.1021/jm9805236

Reference yield:

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 200801-91-8
5-<2-(methylthio)pyrimidin-4-yl>-4-<3-(trifluoromethyl)phenyl>-2-<4-(N-(benzyloxycarbonyl)piperidinyl)>imidazole

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / Et₃N / CH₂Cl₂ / 0.5 h / 5 °C

2: 1.) LDA / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 5 min

3: 100 percent / aq. NaNO₂, HOAc / 1 h / 5 - 20 °C

4: 97 percent / ammonium acetate, AcOH / 2 h / Heating

5: TiCl₃, aq. HCl / methanol / 3 h / 20 °C

With ammonium acetate; hydrogenchloride; titanium(III) chloride; acetic acid; triethylamine; lithium diisopropyl amide; sodium nitrite; In methanol; dichloromethane;
DOI:10.1021/jm9805236