Ethyl 4-hydroxy-2-phenylbenzo[b]thiophene-6-carboxylate

Base Information

Chemical Name:Ethyl 4-hydroxy-2-phenylbenzo[b]thiophene-6-carboxylate
CAS No.:894779-29-4
Molecular Formula:C₁₇H₁₄O₃S
Molecular Weight:298.362
Hs Code.:
DSSTox Substance ID:DTXSID601205439

Synonyms:Ethyl 4-hydroxy-2-phenylbenzo[b]thiophene-6-carboxylate;DTXSID601205439;894779-29-4

Suppliers and Price of Ethyl 4-hydroxy-2-phenylbenzo[b]thiophene-6-carboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Ethyl 4-hydroxy-2-phenylbenzo[b]thiophene-6-carboxylate

Chemical Property:

XLogP3:4.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:298.06636548
Heavy Atom Count:21
Complexity:367

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CCOC(=O)C1=CC(=C2C=C(SC2=C1)C3=CC=CC=C3)O

Technology Process of Ethyl 4-hydroxy-2-phenylbenzo[b]thiophene-6-carboxylate

There total 2 articles about Ethyl 4-hydroxy-2-phenylbenzo[b]thiophene-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-[1-(5-Phenyl-thiophen-2-yl)-meth-(E)-ylidene]-succinic acid 1-ethyl ester

: 894779-29-4
4-hydroxy-2-phenylbenzo[b]thiophene-6-carboxylic acid ethyl ester

Guidance literature:: 2-[1-(5-Phenyl-thiophen-2-yl)-meth-(E)-ylidene]-succinic acid 1-ethyl ester; With sodium acetate; acetic anhydride; for 5h; Heating;

With potassium carbonate; In ethanol; for 18h; Heating;
DOI:10.1021/jm0510732

Reference yield:

: 19163-21-4
5-phenylthiophene-2-carboxaldehyde

: 894779-29-4
4-hydroxy-2-phenylbenzo[b]thiophene-6-carboxylic acid ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: t-BuOK / 2-methyl-propan-2-ol / 1.5 h / Heating

2.1: Ac₂O; NaOAc / 5 h / Heating

2.2: 5.4 g / K₂CO₃ / ethanol / 18 h / Heating

With potassium tert-butylate; sodium acetate; acetic anhydride; In tert-butyl alcohol; 1.1: Stobbe condensation;
DOI:10.1021/jm0510732