4-(tert-butyldimethylsilanyloxy)-2-phenylbenzo[b]thiophene-6-carbaldehyde

Base Information

Chemical Name:4-(tert-butyldimethylsilanyloxy)-2-phenylbenzo[b]thiophene-6-carbaldehyde
CAS No.:894779-41-0
Molecular Formula:C₂₁H₂₄O₂SSi
Molecular Weight:368.572
Hs Code.:

Synonyms:4-(tert-butyldimethylsilanyloxy)-2-phenylbenzo[b]thiophene-6-carbaldehyde

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Chemical Property of 4-(tert-butyldimethylsilanyloxy)-2-phenylbenzo[b]thiophene-6-carbaldehyde

Chemical Property:

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Technology Process of 4-(tert-butyldimethylsilanyloxy)-2-phenylbenzo[b]thiophene-6-carbaldehyde

There total 6 articles about 4-(tert-butyldimethylsilanyloxy)-2-phenylbenzo[b]thiophene-6-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [4-(tert-butyl-dimethyl-silanyloxy)-2-phenyl-benzo[b]thiophen-6-yl]-methanol

: 894779-41-0
4-(tert-butyldimethylsilanyloxy)-2-phenylbenzo[b]thiophene-6-carbaldehyde

Guidance literature:: With manganese(IV) oxide; In tetrachloromethane; at 20 ℃; for 2h;
DOI:10.1021/jm0510732

Reference yield:

: 894779-29-4
4-hydroxy-2-phenylbenzo[b]thiophene-6-carboxylic acid ethyl ester

: 894779-41-0
4-(tert-butyldimethylsilanyloxy)-2-phenylbenzo[b]thiophene-6-carbaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1: 95 percent / imidazole / CH₂Cl₂ / 18 h / 20 °C

2: LiAlH₄ / tetrahydrofuran / 2.5 h / 0 - 20 °C

3: 665 mg / MnO₂ / CCl₄ / 2 h / 20 °C

With 1H-imidazole; manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1021/jm0510732

Reference yield:

: 2-[1-(5-Phenyl-thiophen-2-yl)-meth-(E)-ylidene]-succinic acid 1-ethyl ester

: 894779-41-0
4-(tert-butyldimethylsilanyloxy)-2-phenylbenzo[b]thiophene-6-carbaldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: Ac₂O; NaOAc / 5 h / Heating

1.2: 5.4 g / K₂CO₃ / ethanol / 18 h / Heating

2.1: 95 percent / imidazole / CH₂Cl₂ / 18 h / 20 °C

3.1: LiAlH₄ / tetrahydrofuran / 2.5 h / 0 - 20 °C

4.1: 665 mg / MnO₂ / CCl₄ / 2 h / 20 °C

With 1H-imidazole; manganese(IV) oxide; lithium aluminium tetrahydride; sodium acetate; acetic anhydride; In tetrahydrofuran; tetrachloromethane; dichloromethane;
DOI:10.1021/jm0510732