(E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-2-chlorobenzoyl oxime

Base Information

• Chemical Name: (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-2-chlorobenzoyl oxime
• CAS No.: 1563040-26-5
• Molecular Formula: C₁₉H₁₆ClN₃O₂
• Molecular Weight: 353.808
• Mol file: 1563040-26-5.mol

Synonyms:(E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-2-chlorobenzoyl oxime

Chemical Property of (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-2-chlorobenzoyl oxime

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-2-chlorobenzoyl oxime

There total 3 articles about (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-2-chlorobenzoyl oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

(1E)-N-hydroxy-3-(1H-imidazol-1-yl)-1-phenylpropan-1-imine (1563040-12-9) + ortho-chlorobenzoic acid (118-91-2) → (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-2-chlorobenzoyl oxime (1563040-26-5)

Guidance literature:

With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 18h;

DOI:10.3390/molecules181012208

Reference yield:

acetophenone (98-86-2) → (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-2-chlorobenzoyl oxime (1563040-26-5)

Guidance literature:

Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol / 2 h / Reflux

2: water / 5 h / Reflux

3: hydroxylamine hydrochloride; potassium hydroxide / ethanol / 18 h / Reflux

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 18 h / 20 °C

With hydrogenchloride; dmap; hydroxylamine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; dichloromethane; water;

DOI:10.3390/molecules181012208

Reference yield:

3-(dimethylamino)propiophenone hydrochloride (879-72-1) → (E)-3-(1H-imidazol-1-yl)-1-phenylpropan-1-one O-2-chlorobenzoyl oxime (1563040-26-5)

Guidance literature:

Multi-step reaction with 3 steps

1: water / 5 h / Reflux

2: hydroxylamine hydrochloride; potassium hydroxide / ethanol / 18 h / Reflux

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / dichloromethane / 18 h / 20 °C

With dmap; hydroxylamine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; potassium hydroxide; In ethanol; dichloromethane; water;

DOI:10.3390/molecules181012208

upstream raw materials:

3-(dimethylamino)propiophenone hydrochloride

acetophenone

(1E)-N-hydroxy-3-(1H-imidazol-1-yl)-1-phenylpropan-1-imine

ortho-chlorobenzoic acid