2-amino-5-{4-[3-(dimethylamino)-3-oxopropyl]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

Base Information

Chemical Name:2-amino-5-{4-[3-(dimethylamino)-3-oxopropyl]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate
CAS No.:1376514-35-0
Molecular Formula:C₃₃H₄₆N₄O₅S
Molecular Weight:610.818
Hs Code.:

Synonyms:2-amino-5-{4-[3-(dimethylamino)-3-oxopropyl]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

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Chemical Property of 2-amino-5-{4-[3-(dimethylamino)-3-oxopropyl]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

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Technology Process of 2-amino-5-{4-[3-(dimethylamino)-3-oxopropyl]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

There total 7 articles about 2-amino-5-{4-[3-(dimethylamino)-3-oxopropyl]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1376514-34-9
(E)-2-amino-5-{4-[3-(dimethylamino)-3-oxoprop-1-enyl]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

: 1376514-35-0
2-amino-5-{4-[3-(dimethylamino)-3-oxopropyl]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; ethyl acetate; for 3h; under 2250.23 Torr;

Reference yield:

: 854778-42-0
4-bromo-1-(bromomethyl)-2-methoxybenzene

: 1376514-35-0
2-amino-5-{4-[3-(dimethylamino)-3-oxopropyl]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

1.2: 16 h / 70 °C

2.1: methanol / 16 h / 65 °C

3.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

4.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / 24 h / Reflux

5.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3 h / 2250.23 Torr

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogen; sodium hydride; triethylamine; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; ethanol; ethyl acetate; mineral oil;

Reference yield:

: 17102-63-5
(4-bromo-2-methoxyphenyl)methanol

: 1376514-35-0
2-amino-5-{4-[3-(dimethylamino)-3-oxopropyl]-2-methoxybenzyl}-6-methylpyrimidin-4-yl 2,4,6-triisopropylbenzenesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1.1: phosphorus tribromide / dichloromethane / 0.67 h / 0 °C

2.1: sodium hydride / tetrahydrofuran; mineral oil / 0.33 h / 0 °C

2.2: 16 h / 70 °C

3.1: methanol / 16 h / 65 °C

4.1: 1,4-diaza-bicyclo[2.2.2]octane / tetrahydrofuran / 7 h / 30 °C

5.1: triethylamine / palladium diacetate; tris-(o-tolyl)phosphine / 24 h / Reflux

6.1: hydrogen / palladium 10% on activated carbon / ethyl acetate; ethanol / 3 h / 2250.23 Torr

With 1,4-diaza-bicyclo[2.2.2]octane; hydrogen; phosphorus tribromide; sodium hydride; triethylamine; palladium 10% on activated carbon; palladium diacetate; tris-(o-tolyl)phosphine; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; mineral oil;