ethyl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

Base Information

Chemical Name:ethyl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate
CAS No.:1448055-86-4
Molecular Formula:C₁₉H₂₄F₂N₂O₃
Molecular Weight:366.408
Hs Code.:

Synonyms:ethyl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

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Chemical Property of ethyl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

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Technology Process of ethyl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

There total 5 articles about ethyl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1189569-73-0
(8R)-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one

: 105-36-2
ethyl bromoacetate

: 1448055-86-4
ethyl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

Guidance literature:: (8R)-8-(3,5-difluorophenyl)-8-methyl-6,9-diazaspiro[4.5]decan-10-one; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 0.0833333h;

ethyl bromoacetate; In tetrahydrofuran; at 0 - 20 ℃;
DOI:10.1021/ml400199p

Reference yield:

: 957122-15-5
tert-butyl [1-(3,5-difluorophenyl)-1-methyl-2-oxoethyl]carbamate

: 1448055-86-4
ethyl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / methanol / 0.5 h / 20 °C

1.2: 0.5 h / pH 5

2.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

3.1: acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 80 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C

4.2: 0 - 20 °C

With hydrogenchloride; sodium hydride; acetic acid; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate; mineral oil;
DOI:10.1021/ml400199p

Reference yield:

: 957122-14-4
tert-butyl 2-[(tert-butoxycarbonyl)amino]-2-(3,5-difluorophenyl)propanoate

: 1448055-86-4
ethyl [(8R)-8-(3,5-difluorophenyl)-8-methyl-10-oxo-6,9-diazaspiro[4.5]dec-9-yl]acetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / -78 °C

2.1: acetic acid / methanol / 0.5 h / 20 °C

2.2: 0.5 h / pH 5

3.1: hydrogenchloride / ethyl acetate / 0.5 h / 0 °C

4.1: acetic acid / 5,5-dimethyl-1,3-cyclohexadiene / 3 h / 80 °C

5.1: sodium hydride / tetrahydrofuran; mineral oil / 0.08 h / 0 °C

5.2: 0 - 20 °C

With hydrogenchloride; lithium aluminium tetrahydride; sodium hydride; acetic acid; In tetrahydrofuran; methanol; 5,5-dimethyl-1,3-cyclohexadiene; ethyl acetate; mineral oil;
DOI:10.1021/ml400199p