2-Amino-5-bromo-3-ethoxypyrazine

Base Information

• Chemical Name: 2-Amino-5-bromo-3-ethoxypyrazine
• CAS No.: 77112-66-4
• Molecular Formula: C₆H₈BrN₃O
• Molecular Weight: 218.053
• Hs Code.: 2933990090
• DSSTox Substance ID: DTXSID30506484
• Mol file: 77112-66-4.mol

Synonyms:2-AMINO-5-BROMO-3-ETHOXYPYRAZINE;77112-66-4;5-BROMO-3-ETHOXYPYRAZIN-2-AMINE;SCHEMBL3149912;DTXSID30506484;SZVPSYHZBDHGGE-UHFFFAOYSA-N;AMY26839;MFCD08460057;AKOS015919574;CS-W021563;FS-3351;MB06257;FT-0646535;A865361

Chemical Property of 2-Amino-5-bromo-3-ethoxypyrazine

Chemical Property:

• Vapor Pressure: 0.00494mmHg at 25°C
• Melting Point: 123-124 °C(Solv: hexane (110-54-3); benzene (71-43-2))
• Refractive Index: 1.592
• Boiling Point: 276 °C at 760 mmHg
• PKA: 1.97±0.10(Predicted)
• Flash Point: 120.7 °C
• PSA: 61.03000
• Density: 1.616 g/cm³
• LogP: 1.80120
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 216.98507
• Heavy Atom Count: 11
• Complexity: 124

Purity/Quality:

98%min ^*data from raw suppliers

2-Amino-5-bromo-3-ethoxypyrazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=NC(=CN=C1N)Br

Technology Process of 2-Amino-5-bromo-3-ethoxypyrazine

There total 3 articles about 2-Amino-5-bromo-3-ethoxypyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

sodium ethanolate (141-52-6) + 2-amino-3,5-dibromopyrazine (24241-18-7) → 2-amino-5-bromo-3-ethoxypyrazine (77112-66-4)

Guidance literature:

In ethanol; for 8h; Reflux;

Reference yield: 75.0%

ethanol (64-17-5) + 2-amino-3,5-dibromopyrazine (24241-18-7) → 2-amino-5-bromo-3-ethoxypyrazine (77112-66-4)

Guidance literature:

With sodium; for 1.5h; Heating;

Reference yield:

2-amino-3,5-dibromopyrazine (24241-18-7) → 2-amino-5-bromo-3-ethoxypyrazine (77112-66-4)

Guidance literature:

With sodium ethanolate; In ethanol;

upstream raw materials:

ethanol

2-amino-3,5-dibromopyrazine

sodium ethanolate

Refernces

• 1、 -. "N-heterocyclyl sulphonamide derivatives and their use as endothelin antagonists". . . Retrieved 2008/06/13.