7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine

Base Information

Chemical Name:7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine
CAS No.:1027345-33-0
Molecular Formula:C₂₅H₂₄ClN₅
Molecular Weight:429.952
Hs Code.:

Synonyms:7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine

Suppliers and Price of 7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine

There total 8 articles about 7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1027345-32-9
2-amino-4-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)benzonitrile

: 3473-63-0
formamidine acetic acid

: 1027345-33-0
7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine

Guidance literature:: In 2-methoxy-ethanol; for 3h; Heating / reflux;

Reference yield:

: 1027345-29-4
4-(4-(2-bromobenzyl)piperazin-1-yl)-2-nitrobenzonitrile

: 1027345-33-0
7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 4 h / 90 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: iron; acetic acid / 0.17 h / 90 °C / Inert atmosphere

3.1: ethyl methyl ether / 3 h / 120 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; iron; sodium carbonate; acetic acid; In 1,2-dimethoxyethane; ethanol; ethyl methyl ether; water; 1.1: Suzuki coupling;
DOI:10.1021/jm101596e

Reference yield:

: 4110-33-2
2,4-dinitrobenzonitrile

: 1027345-33-0
7-(4-((4'-chloro-(1,1'-biphenyl)-2-yl)methyl)piperazin-1-yl)quinazolin-4-amine

Guidance literature:: Multi-step reaction with 6 steps

1.1: dimethyl sulfoxide / 72 h / 25 °C / Inert atmosphere

2.1: acetonitrile / 2 h / Inert atmosphere

3.1: triethylamine / isopropyl alcohol / 3 h / Inert atmosphere

4.1: bis-triphenylphosphine-palladium(II) chloride; sodium carbonate / 1,2-dimethoxyethane; ethanol; water / 4 h / 90 °C / Inert atmosphere

4.2: Inert atmosphere

5.1: iron; acetic acid / 0.17 h / 90 °C / Inert atmosphere

6.1: ethyl methyl ether / 3 h / 120 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; iron; sodium carbonate; acetic acid; triethylamine; In 1,2-dimethoxyethane; ethanol; ethyl methyl ether; water; dimethyl sulfoxide; isopropyl alcohol; acetonitrile; 4.1: Suzuki coupling;
DOI:10.1021/jm101596e