[(R)-2-Methoxy-1-phenylethyl]isopropylamine

Base Information

Chemical Name:[(R)-2-Methoxy-1-phenylethyl]isopropylamine
CAS No.:112211-93-5
Molecular Formula:C₁₂H₁₉NO
Molecular Weight:193.289
Hs Code.:
DSSTox Substance ID:DTXSID801192062
Nikkaji Number:J416.095I

Synonyms:112211-93-5;SCHEMBL19087177;DTXSID801192062;[(R)-2-Methoxy-1-phenylethyl]isopropylamine;(alphaR)-alpha-(Methoxymethyl)-N-(1-methylethyl)benzenemethanamine

Suppliers and Price of [(R)-2-Methoxy-1-phenylethyl]isopropylamine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [(R)-2-Methoxy-1-phenylethyl]isopropylamine

Chemical Property:

XLogP3:2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:5
Exact Mass:193.146664230
Heavy Atom Count:14
Complexity:141

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)NC(COC)C1=CC=CC=C1
Isomeric SMILES:CC(C)N[C@@H](COC)C1=CC=CC=C1

Technology Process of [(R)-2-Methoxy-1-phenylethyl]isopropylamine

There total 6 articles about [(R)-2-Methoxy-1-phenylethyl]isopropylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 112211-92-4
(R)-N-(2-Hydroxy-1-phenylethyl)-N-isopropylamine

: 74-88-4
methyl iodide

: 112211-93-5
(R)-2-isopropylamino-1-methoxy-2-phenylethane

Guidance literature:: With sodium hydride; In tetrahydrofuran; Ambient temperature;
DOI:10.1016/S0040-4020(01)81078-4

Reference yield: 78.0%

: 64715-86-2
(R)-O-methylphenylglycinol

: 67-64-1
acetone

: 112211-93-5
(R)-2-isopropylamino-1-methoxy-2-phenylethane

Guidance literature:: With sodium cyanoborohydride; In methanol; at 0 ℃; for 1h;
DOI:10.1016/S0040-4020(97)00288-3

Reference yield:

: 56613-80-0
D-2-phenylglycinol

: 112211-93-5
(R)-2-isopropylamino-1-methoxy-2-phenylethane

Guidance literature:: Multi-step reaction with 3 steps

1.1: 100 percent / pTsOH / benzene / 72 h / Heating

2.1: 93 percent / H₂ / 10 percent Pd/C / tetrahydrofuran / 12 h / 3040 Torr

3.1: NaH / tetrahydrofuran / 0.5 h / 40 °C

3.2: 76 percent / tetrahydrofuran / 20 °C

With hydrogen; sodium hydride; toluene-4-sulfonic acid; palladium on activated charcoal; In tetrahydrofuran; benzene; 1.1: Condensation / 2.1: Catalytic hydrogenation / 3.1: Metallation / 3.2: Etherification;
DOI:10.1002/(SICI)1521-3765(19990802)5:8<2348::AID-CHEM2348>3.0.CO;2-A