5-(4,4'-dimethoxytrityl)-3-O-tert-butyldimethylsilyloxy-1,2-dideoxy-1-C-(2-hydroxyethyl)-β-D-erythro-pentofuranose

Base Information

• Chemical Name: 5-(4,4'-dimethoxytrityl)-3-O-tert-butyldimethylsilyloxy-1,2-dideoxy-1-C-(2-hydroxyethyl)-β-D-erythro-pentofuranose
• CAS No.: 1015230-42-8
• Molecular Formula: C₃₄H₄₆O₆Si
• Molecular Weight: 578.821
• Mol file: 1015230-42-8.mol

Synonyms:5-(4,4'-dimethoxytrityl)-3-O-tert-butyldimethylsilyloxy-1,2-dideoxy-1-C-(2-hydroxyethyl)-β-D-erythro-pentofuranose

Chemical Property of 5-(4,4'-dimethoxytrityl)-3-O-tert-butyldimethylsilyloxy-1,2-dideoxy-1-C-(2-hydroxyethyl)-β-D-erythro-pentofuranose

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-(4,4'-dimethoxytrityl)-3-O-tert-butyldimethylsilyloxy-1,2-dideoxy-1-C-(2-hydroxyethyl)-β-D-erythro-pentofuranose

There total 5 articles about 5-(4,4'-dimethoxytrityl)-3-O-tert-butyldimethylsilyloxy-1,2-dideoxy-1-C-(2-hydroxyethyl)-β-D-erythro-pentofuranose which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Acetic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester → 5-(4,4'-dimethoxytrityl)-3-O-tert-butyldimethylsilyloxy-1,2-dideoxy-1-C-(2-hydroxyethyl)-β-D-erythro-pentofuranose (1015230-42-8)

Guidance literature:

With lithium borohydride; In tetrahydrofuran; at 20 ℃; for 6h;

DOI:10.1080/07328319808004683

Reference yield:

tert-butyldimethylsilyl chloride (18162-48-6) → 5-(4,4'-dimethoxytrityl)-3-O-tert-butyldimethylsilyloxy-1,2-dideoxy-1-C-(2-hydroxyethyl)-β-D-erythro-pentofuranose (1015230-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: LiBH₄ / tetrahydrofuran / 6 h / 20 °C

With pyridine; lithium borohydride; In tetrahydrofuran;

DOI:10.1080/07328319808004683

Reference yield:

Acetic acid 2-{(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-ethyl ester → 5-(4,4'-dimethoxytrityl)-3-O-tert-butyldimethylsilyloxy-1,2-dideoxy-1-C-(2-hydroxyethyl)-β-D-erythro-pentofuranose (1015230-42-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: LiBH₄ / tetrahydrofuran / 6 h / 20 °C

With pyridine; lithium borohydride; In tetrahydrofuran;

DOI:10.1080/07328319808004683

upstream raw materials:

4,4'-dimethoxytrityl chloride

ethyl [2-deoxy-5-O-(4,4'-dimethoxytrityl)-β-D-erythro-pentofuranosyl]acetate

tert-butyldimethylsilyl chloride

Downstream raw materials:

4-Oxo-pentanoic acid 2-[(2S,4S,5R)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-(tert-butyl-dimethyl-silanyloxy)-tetrahydro-furan-2-yl]-ethyl ester

2-[(2S,4S,5R)-5-{[bis(4-methoxyphenyl)(phenyl)methoxy]methyl}-4-hydroxytetrahydrofuran-2-yl]ethyl 4-oxopentanoate

5-(4,4'-dimethoxytrityl)-3-O-tert-butyldimethylsilyloxy-1,2-dideoxy-1-C-(2-phthalimidoxyethyl)-α-D-erythro-pentofuranose