<(tert-Butyloxy)carbonyl>-L-valyl-L-valyl-L-aspartic Acid Dibenzyl Ester

Base Information

• Chemical Name: <(tert-Butyloxy)carbonyl>-L-valyl-L-valyl-L-aspartic Acid Dibenzyl Ester
• CAS No.: 70853-22-4
• Molecular Formula: C₃₃H₄₅N₃O₈
• Molecular Weight: 611.736
• Mol file: 70853-22-4.mol

Synonyms:<(tert-Butyloxy)carbonyl>-L-valyl-L-valyl-L-aspartic Acid Dibenzyl Ester

Chemical Property of <(tert-Butyloxy)carbonyl>-L-valyl-L-valyl-L-aspartic Acid Dibenzyl Ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of <(tert-Butyloxy)carbonyl>-L-valyl-L-valyl-L-aspartic Acid Dibenzyl Ester

There total 6 articles about <(tert-Butyloxy)carbonyl>-L-valyl-L-valyl-L-aspartic Acid Dibenzyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

t-Boc-L-valine (13734-41-3) → <(tert-Butyloxy)carbonyl>-L-valyl-L-valyl-L-aspartic Acid Dibenzyl Ester (70853-22-4)

Guidance literature:

Multi-step reaction with 3 steps

1: DCC, HOBt, Et₃N

2: TFA

3: DCC, HOBt, Et₃N

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid;

DOI:10.1271/bbb1961.46.1865

Reference yield:

dibenzyl L-aspartate toluene-4-sulphonate (2886-33-1) → <(tert-Butyloxy)carbonyl>-L-valyl-L-valyl-L-aspartic Acid Dibenzyl Ester (70853-22-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / triethylamine, DCC, HOBt / CH₂Cl₂ / 5 °C

2: 1.) HCl, 2.) triethylamine, DCC, HOBt

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In dichloromethane;

DOI:10.1021/jo01300a004

Reference yield:

t-Boc-L-valine (13734-41-3) + Boc-Val-Asp(OBzl)-OBzl (70853-19-9) → <(tert-Butyloxy)carbonyl>-L-valyl-L-valyl-L-aspartic Acid Dibenzyl Ester (70853-22-4)

Guidance literature:

With hydrogenchloride; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; Yield given. Multistep reaction;

DOI:10.1021/jo01300a004

upstream raw materials:

t-Boc-L-valine

Boc-Val-Asp(OBzl)-OBzl

Val-Asp(OBzl)-OBzl

dibenzyl L-aspartate

Downstream raw materials:

(2S,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester

(2R,3R)-<3-<<(tert-Butyloxy)carbonyl>amino>-2-hydroxy-5-methylhexanoyl>-L-valyl-L-valyl-aspartic Acid Dibenzyl Ester

Val-Val-Asp(OBzl)-OBzl

(2R,3R)-(3-Amino-2-hydroxy-5-methylhexanoyl)-L-valyl-L-valyl-L-aspartic Acid