(Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole

Base Information

Chemical Name:(Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole
CAS No.:1293294-90-2
Molecular Formula:C₂₀H₂₀FN₃O
Molecular Weight:337.397
Hs Code.:

Synonyms:(Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole

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Chemical Property of (Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole

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Technology Process of (Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole

There total 3 articles about (Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1293294-69-5
2-{fluoro[1-(3-phenylpropyl)-1H-1,2,3-triazol-4-yl]methylsulfonyl}benzo[d]-thiazole

: 123-11-5
4-methoxy-benzaldehyde

: (E)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole

: 1293294-90-2
(Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole

Guidance literature:: With lithium hexamethyldisilazane; In tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N-dimethyl-formamide; at -78 ℃; for 0.0833333h; optical yield given as %de; Inert atmosphere;
DOI:10.1039/c0cc05083k

Reference yield:

: 27126-20-1
(3-azidopropyl)benzene

: (E)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole

: 1293294-90-2
(Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 2 steps

1: tetrakis(actonitrile)copper(I) hexafluorophosphate; silver tetrafluoroborate / methanol; dichloromethane / 20 °C

2: lithium hexamethyldisilazane / tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N-dimethyl-formamide / 0.08 h / -78 °C / Inert atmosphere

With silver tetrafluoroborate; tetrakis(actonitrile)copper(I) hexafluorophosphate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; dichloromethane; N,N-dimethyl-formamide; 1: Huisgen ligation reaction / 2: Julia Olefin synthesis;
DOI:10.1039/c0cc05083k

Reference yield:

: 637-59-2
1-Bromo-3-phenylpropane

: (E)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole

: 1293294-90-2
(Z)-4-[1-fluoro-2-(4-methoxyphenyl)vinyl]-1-(3-phenylpropyl)-1H-1,2,3-triazole

Guidance literature:: Multi-step reaction with 3 steps

1: sodium azide / N,N-dimethyl-formamide / 7 h / 80 °C

2: tetrakis(actonitrile)copper(I) hexafluorophosphate; silver tetrafluoroborate / methanol; dichloromethane / 20 °C

3: lithium hexamethyldisilazane / tetrahydrofuran; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; N,N-dimethyl-formamide / 0.08 h / -78 °C / Inert atmosphere

With silver tetrafluoroborate; sodium azide; tetrakis(actonitrile)copper(I) hexafluorophosphate; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone; dichloromethane; N,N-dimethyl-formamide; 2: Huisgen ligation reaction / 3: Julia Olefin synthesis;
DOI:10.1039/c0cc05083k