(S)-5-chloro-7-((cyclohexylmethyl)amino)-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indole-2-carboxamide

Base Information

Chemical Name:(S)-5-chloro-7-((cyclohexylmethyl)amino)-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indole-2-carboxamide
CAS No.:1403506-43-3
Molecular Formula:C₂₇H₃₃ClN₄O₅S
Molecular Weight:561.102
Hs Code.:

Synonyms:(S)-5-chloro-7-((cyclohexylmethyl)amino)-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indole-2-carboxamide

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Chemical Property of (S)-5-chloro-7-((cyclohexylmethyl)amino)-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indole-2-carboxamide

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Technology Process of (S)-5-chloro-7-((cyclohexylmethyl)amino)-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indole-2-carboxamide

There total 12 articles about (S)-5-chloro-7-((cyclohexylmethyl)amino)-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1403506-12-6
(S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide

: 5664-21-1
cyclohexylacetaldehyde

: 1403506-43-3
(S)-5-chloro-7-((cyclohexylmethyl)amino)-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indole-2-carboxamide

Guidance literature:: (S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide; cyclohexylacetaldehyde; With N-ethyl-N,N-diisopropylamine; In dichloromethane; for 2h;

With sodium tris(acetoxy)borohydride; In dichloromethane;

Reference yield:

: 89-63-4
4-Chloro-2-nitroaniline

: 1403506-43-3
(S)-5-chloro-7-((cyclohexylmethyl)amino)-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: potassium hydroxide / ethanol; water / 0 - 10 °C / Industry scale

1.2: 0.5 h / -5 - 0 °C

2.1: Polyphosphoric acid (PPA) / 110 °C

3.1: acetic anhydride; sulfuric acid / 0 - 20 °C

3.2: 0 - 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12 h / 10 °C

5.1: triethylamine / dichloromethane / 4 h

6.1: ammonium chloride; iron / ethanol / 80 - 85 °C

7.1: ammonia / isopropyl alcohol / 110 °C / Sealed tube

8.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h

With oxalyl dichloride; sulfuric acid; ammonia; acetic anhydride; iron; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; N,N-dimethyl-formamide; In ethanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 71031-03-3,71031-02-2
(R)-phenyl glycidyl ether

: 1403506-43-3
(S)-5-chloro-7-((cyclohexylmethyl)amino)-3-((2-(phenoxymethyl)morpholino)sulfonyl)-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / 0.17 h / 10 - 20 °C

1.2: 15 h / 45 - 50 °C

2.1: ammonium formate / palladium 10% on activated carbon / 1 h / 20 °C / Reflux; Cooling with dry ice

3.1: triethylamine / dichloromethane / 4 h

4.1: ammonium chloride; iron / ethanol / 80 - 85 °C

5.1: ammonia / isopropyl alcohol / 110 °C / Sealed tube

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 h

With ammonia; ammonium formate; iron; ammonium chloride; triethylamine; N-ethyl-N,N-diisopropylamine; sodium hydroxide; palladium 10% on activated carbon; In ethanol; dichloromethane; water; isopropyl alcohol;