(S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide

Base Information

Chemical Name:(S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide
CAS No.:1403506-12-6
Molecular Formula:C₂₀H₂₁ClN₄O₅S
Molecular Weight:464.93
Hs Code.:

Synonyms:(S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide

Suppliers and Price of (S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide

Chemical Property:

Purity/Quality:

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Technology Process of (S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide

There total 10 articles about (S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403506-11-5
(S)-ethyl 7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxylate

: 1403506-12-6
(S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide

Guidance literature:: With ammonia; In isopropyl alcohol; at 110 ℃; Sealed tube;

Reference yield:

: 71031-03-3,71031-02-2
(R)-phenyl glycidyl ether

: 1403506-12-6
(S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide / water / 0.17 h / 10 - 20 °C

1.2: 15 h / 45 - 50 °C

2.1: ammonium formate / palladium 10% on activated carbon / 1 h / 20 °C / Reflux; Cooling with dry ice

3.1: triethylamine / dichloromethane / 4 h

4.1: ammonium chloride; iron / ethanol / 80 - 85 °C

5.1: ammonia / isopropyl alcohol / 110 °C / Sealed tube

With ammonia; ammonium formate; iron; ammonium chloride; triethylamine; sodium hydroxide; palladium 10% on activated carbon; In ethanol; dichloromethane; water; isopropyl alcohol;

Reference yield:

: 89-63-4
4-Chloro-2-nitroaniline

: 1403506-12-6
(S)-7-amino-5-chloro-3-(2-(phenoxymethyl)morpholinosulfonyl)-1H-indole-2-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide / ethanol; water / 0 - 10 °C / Industry scale

1.2: 0.5 h / -5 - 0 °C

2.1: Polyphosphoric acid (PPA) / 110 °C

3.1: acetic anhydride; sulfuric acid / 0 - 20 °C

3.2: 0 - 20 °C

4.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 12 h / 10 °C

5.1: triethylamine / dichloromethane / 4 h

6.1: ammonium chloride; iron / ethanol / 80 - 85 °C

7.1: ammonia / isopropyl alcohol / 110 °C / Sealed tube

With oxalyl dichloride; sulfuric acid; ammonia; acetic anhydride; iron; ammonium chloride; triethylamine; potassium hydroxide; N,N-dimethyl-formamide; In ethanol; dichloromethane; water; isopropyl alcohol;