ethyl 4-[(3-chloro-2-fluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate

Base Information

Chemical Name:ethyl 4-[(3-chloro-2-fluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate
CAS No.:1041853-33-1
Molecular Formula:C₁₉H₁₇ClFN₃O₄
Molecular Weight:405.813
Hs Code.:

Synonyms:ethyl 4-[(3-chloro-2-fluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate

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Chemical Property of ethyl 4-[(3-chloro-2-fluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate

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Technology Process of ethyl 4-[(3-chloro-2-fluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate

There total 6 articles about ethyl 4-[(3-chloro-2-fluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1041853-11-5
ethyl 4-chloro-6,7-dimethoxycinnoline-3-carboxylatre

: 2106-04-9
3-chloro-2-fluoroaniline

: 1041853-33-1
ethyl 4-[(3-chloro-2-fluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate

Guidance literature:: With acetic acid; In ethanol; at 75 ℃;
DOI:10.1016/j.bmcl.2011.01.033

Reference yield:

: 4101-30-8
2-amino-4,5-dimethoxyacetophenone

: 1041853-33-1
ethyl 4-[(3-chloro-2-fluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: hydrogenchloride; sodium nitrite / water / 0 °C

2: sodium hydride / tetrahydrofuran / Reflux

3: trifluoroacetic acid / 0 °C

4: trichlorophosphate / Reflux

5: acetic acid / ethanol / 75 °C

With hydrogenchloride; sodium hydride; acetic acid; trifluoroacetic acid; sodium nitrite; trichlorophosphate; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmcl.2011.01.033

Reference yield:

: 1284175-28-5
C₁₄H₁₉N₃O₃

: 1041853-33-1
ethyl 4-[(3-chloro-2-fluorophenyl)amino]-6,7-dimethoxycinnoline-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / Reflux

2: trifluoroacetic acid / 0 °C

3: trichlorophosphate / Reflux

4: acetic acid / ethanol / 75 °C

With sodium hydride; acetic acid; trifluoroacetic acid; trichlorophosphate; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2011.01.033