(3R)-3-methyl-1-[(1R)-1-(N-methylcarbamoyl)-1-phenylmethyl]-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

Base Information

Chemical Name:(3R)-3-methyl-1-[(1R)-1-(N-methylcarbamoyl)-1-phenylmethyl]-3-(2-nitrobenzenesulfonylamino)azetidin-2-one
CAS No.:1415380-10-7
Molecular Formula:C₁₉H₂₀N₄O₆S
Molecular Weight:432.457
Hs Code.:

Synonyms:(3R)-3-methyl-1-[(1R)-1-(N-methylcarbamoyl)-1-phenylmethyl]-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

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Chemical Property of (3R)-3-methyl-1-[(1R)-1-(N-methylcarbamoyl)-1-phenylmethyl]-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

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Technology Process of (3R)-3-methyl-1-[(1R)-1-(N-methylcarbamoyl)-1-phenylmethyl]-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

There total 5 articles about (3R)-3-methyl-1-[(1R)-1-(N-methylcarbamoyl)-1-phenylmethyl]-3-(2-nitrobenzenesulfonylamino)azetidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1415380-04-9
(3R)-3-methyl-3-(2-nitrobenzenesulfonylamino)-1-[(R)-1-phenylcarboxymethyl]azetidin-2-one

: 74-89-5
methylamine

: 1415380-10-7
(3R)-3-methyl-1-[(1R)-1-(N-methylcarbamoyl)-1-phenylmethyl]-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/jo302368y

Reference yield:

: C₁₈H₁₉N₃O₆S

: 1415380-10-7
(3R)-3-methyl-1-[(1R)-1-(N-methylcarbamoyl)-1-phenylmethyl]-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: Jones reagent / acetone / 2 h / 0 °C / Inert atmosphere

2: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane; tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

With Jones reagent; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jo302368y

Reference yield:

: 1415379-94-0
C₂₅H₃₇N₃O₇SSi

: 1415380-10-7
(3R)-3-methyl-1-[(1R)-1-(N-methylcarbamoyl)-1-phenylmethyl]-3-(2-nitrobenzenesulfonylamino)azetidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hexamethyldisilazane / tetrahydrofuran / 12 h / Inert atmosphere

2: Jones reagent / acetone / 2 h / 0 °C / Inert atmosphere

3: benzotriazol-1-ol; dicyclohexyl-carbodiimide / dichloromethane; tetrahydrofuran / 12 h / 0 - 20 °C / Inert atmosphere

With Jones reagent; benzotriazol-1-ol; dicyclohexyl-carbodiimide; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; acetone;
DOI:10.1021/jo302368y