(S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid ethyl ester

Base Information

• Chemical Name: (S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid ethyl ester
• CAS No.: 1349854-31-4
• Molecular Formula: C₂₄H₂₆N₂O₄
• Molecular Weight: 406.481
• Mol file: 1349854-31-4.mol

Synonyms:(S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid ethyl ester

Chemical Property of (S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid ethyl ester

There total 5 articles about (S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid ethyl ester (1349854-28-9) + 4,6-dimethyl-2-methylsulfonylpyrimidine (35144-22-0) → (S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid ethyl ester (1349854-31-4)

Guidance literature:

(S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid ethyl ester; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h; Inert atmosphere;

4,6-dimethyl-2-methylsulfonylpyrimidine; In tetrahydrofuran; mineral oil; at 20 ℃; for 4h; Inert atmosphere;

DOI:10.1002/jhet.4223

Reference yield:

ethyl 2-hydroxy-3-methoxy-3,3-diphenylpropionate (876148-89-9) + 4,6-dimethyl-2-methylsulfonylpyrimidine (35144-22-0) → (S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid ethyl ester (1349854-31-4) + C24H26N2O4

Guidance literature:

ethyl 2-hydroxy-3-methoxy-3,3-diphenylpropionate; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

4,6-dimethyl-2-methylsulfonylpyrimidine; In N,N-dimethyl-formamide; at 20 - 90 ℃; for 15h; optical yield given as %ee;

DOI:10.1021/jo201927m

Reference yield:

(S)-3,3-diphenyloxirane-2-carboxylic acid ethyl ester → (S)-2-[(4,6-dimethylpyrimidin-2-yl)oxy]-3-methoxy-3,3-diphenylpropionic acid ethyl ester (1349854-31-4)

Guidance literature:

Multi-step reaction with 2 steps

1: boron trifluoride diethyl etherate / 8 h / 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 3 h / 80 °C

With boron trifluoride diethyl etherate; potassium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

ethyl 2-hydroxy-3-methoxy-3,3-diphenylpropionate

4,6-dimethyl-2-methylsulfonylpyrimidine

(S)-2-hydroxy-3-methoxy-3,3-diphenylpropionic acid ethyl ester

ethyl 3,3-diphenylacrylate

Downstream raw materials:

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