methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]-N-trifluoroacetylglycinate

Base Information

Chemical Name:methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]-N-trifluoroacetylglycinate
CAS No.:165952-42-1
Molecular Formula:C₁₉H₁₅Cl₂F₃N₂O₅
Molecular Weight:479.24
Hs Code.:

Synonyms:methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]-N-trifluoroacetylglycinate

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Chemical Property of methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]-N-trifluoroacetylglycinate

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Technology Process of methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]-N-trifluoroacetylglycinate

There total 6 articles about methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]-N-trifluoroacetylglycinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 407-25-0
trifluoroacetic anhydride

: 165952-41-0
methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]glycinate

: 165952-42-1
methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]-N-trifluoroacetylglycinate

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 0.166667h;
DOI:10.1016/S0968-0896(01)00289-9

Reference yield:

: 57486-68-7
methyl (2-chlorophenyl)acetate

: 165952-42-1
methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]-N-trifluoroacetylglycinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 58 percent / NaH / dimethylformamide / 1 h / 0 °C

2.1: 46 percent / LiBH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 83 percent / DMSO; oxalyl chloride; NEt₃ / CH₂Cl₂ / -78 - 0 °C

4.1: NaOAc / methanol / 0.5 h / 20 °C

4.2: 52 percent / NaBH₃CN / methanol / 3 h / 50 °C

5.1: 96 percent / pyridine / CH₂Cl₂ / 0.17 h / 20 °C

With pyridine; lithium borohydride; oxalyl dichloride; sodium acetate; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Swern oxidation;
DOI:10.1016/S0968-0896(01)00289-9

Reference yield:

: 610-40-2
3,4-dinitro-chlorobenzene

: 165952-42-1
methyl N-[2-(2-chlorophenyl)-2-(5-chloro-2-nitrophenyl)ethyl]-N-trifluoroacetylglycinate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 58 percent / NaH / dimethylformamide / 1 h / 0 °C

2.1: 46 percent / LiBH₄ / tetrahydrofuran / 4 h / 20 °C

3.1: 83 percent / DMSO; oxalyl chloride; NEt₃ / CH₂Cl₂ / -78 - 0 °C

4.1: NaOAc / methanol / 0.5 h / 20 °C

4.2: 52 percent / NaBH₃CN / methanol / 3 h / 50 °C

5.1: 96 percent / pyridine / CH₂Cl₂ / 0.17 h / 20 °C

With pyridine; lithium borohydride; oxalyl dichloride; sodium acetate; sodium hydride; dimethyl sulfoxide; triethylamine; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; 3.1: Swern oxidation;
DOI:10.1016/S0968-0896(01)00289-9