N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

Base Information

Chemical Name:N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine
CAS No.:1388149-22-1
Molecular Formula:C₁₃H₁₁F₄N₃O₃S
Molecular Weight:365.308
Hs Code.:

Synonyms:N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

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Chemical Property of N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

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Technology Process of N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

There total 18 articles about N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1388149-66-3
N-((4aS,5S,7aS)-7a-(2-fluorophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

: 1388149-22-1
N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

Guidance literature:: N-((4aS,5S,7aS)-7a-(2-fluorophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine; With sulfuric acid; nitric acid; trifluoroacetic acid; at 0 ℃; for 1.83333h;

With sodium hydroxide; In water; pH=12; Cooling with ice;

Reference yield:

: 1262803-54-2
N-(((3S,4R,5S)-3-(2-fluorophenyl)-4-(hydroxymethyl)-5-(trifluoromethyl)-tetrahydrofuran-3-yl)carbamothioyl)benzamide

: 1388149-22-1
N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: trifluoromethylsulfonic anhydride; pyridine / -20 - 0 °C

2.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; methanol / 16 h / Reflux

3.1: nitric acid; trifluoroacetic acid; sulfuric acid / 1.83 h / 0 °C

3.2: pH 12 / Cooling with ice

With pyridine; methanol; trifluoromethylsulfonic anhydride; sulfuric acid; nitric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid;

Reference yield:

: 1262799-41-6
(3aR,4S,6aS)-6a-(2-fluorophenyl)-4-(trifluoromethyl)hexahydrofuro[3,4-c]isoxazole

: 1388149-22-1
N-((4aS,5S,7aS)-7a-(2-fluoro-5-nitrophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine

Guidance literature:: Multi-step reaction with 5 steps

1.1: zinc; acetic acid / 0 - 20 °C

2.1: dichloromethane / 18 h / 20 °C

3.1: trifluoromethylsulfonic anhydride; pyridine / -20 - 0 °C

4.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; methanol / 16 h / Reflux

5.1: nitric acid; trifluoroacetic acid; sulfuric acid / 1.83 h / 0 °C

5.2: pH 12 / Cooling with ice

With pyridine; methanol; trifluoromethylsulfonic anhydride; sulfuric acid; nitric acid; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; zinc; In dichloromethane;