Technology Process of N-((4aS,5S,7aS)-7a-(2-fluorophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine
There total 17 articles about N-((4aS,5S,7aS)-7a-(2-fluorophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)amine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
potassium carbonate;
In
methanol;
at 65 ℃;
for 6h;
Reagent/catalyst;
Time;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: hydroquinone / xylene / 18 h / 20 - 128 °C / Industry scale
2.1: zinc; acetic acid / water; tetrahydrofuran / 16 h / 10 - 20 °C
2.2: 30 °C
3.1: ethanol; water / 67 °C
4.1: sodium hydroxide / ethyl acetate; water / 0.42 h / -3 - 5 °C
4.2: 1 h / 5 °C
5.1: trifluoromethylsulfonic anhydride; pyridine / -20 - 0 °C
6.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; methanol / 16 h / Reflux
With
pyridine; methanol; trifluoromethylsulfonic anhydride; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; hydroquinone; sodium hydroxide; zinc;
In
tetrahydrofuran; ethanol; water; ethyl acetate; xylene;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydroxylamine hydrochloride; sodium acetate / methanol / 2 h / 40 - 50 °C / Industry scale
2.1: hydroquinone / xylene / 18 h / 20 - 128 °C / Industry scale
3.1: zinc; acetic acid / water; tetrahydrofuran / 16 h / 10 - 20 °C
3.2: 30 °C
4.1: ethanol; water / 67 °C
5.1: sodium hydroxide / ethyl acetate; water / 0.42 h / -3 - 5 °C
5.2: 1 h / 5 °C
6.1: trifluoromethylsulfonic anhydride; pyridine / -20 - 0 °C
7.1: 1,8-diazabicyclo[5.4.0]undec-7-ene; methanol / 16 h / Reflux
With
pyridine; methanol; trifluoromethylsulfonic anhydride; hydroxylamine hydrochloride; sodium acetate; acetic acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; hydroquinone; sodium hydroxide; zinc;
In
tetrahydrofuran; methanol; ethanol; water; ethyl acetate; xylene;
![N-((4aS,5S,7aS)-7a-(2-fluorophenyl)-5-(trifluoromethyl)-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-2-yl)benzamide](/Databaselist/images/loading.webp)
