Technology Process of 1,3-difluoro-4-iodo-2-methoxybenzene
There total 5 articles about 1,3-difluoro-4-iodo-2-methoxybenzene which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 96 percent / HNO3 / acetic acid / 15 - 20 °C
2: 94 percent / K2CO3 / acetone / 6 h / Heating
3: 99 percent / H2 / 10 percent Pd/C / ethyl acetate
4: 64 percent / I2, aq. NaHCO3 / Ambient temperature
5: 1.) aq. NaNO2, H2SO4, 2.) Cu / 1.) 0 deg C, 30 min, 2.) EtOH, from 60 deg C to 75 deg C, 3 h
With
sulfuric acid; hydrogen; iodine; nitric acid; copper; sodium hydrogencarbonate; potassium carbonate; sodium nitrite;
palladium on activated charcoal;
In
acetic acid; ethyl acetate; acetone;
DOI:10.1021/jm980435l
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / H2 / 10 percent Pd/C / ethyl acetate
2: 64 percent / I2, aq. NaHCO3 / Ambient temperature
3: 1.) aq. NaNO2, H2SO4, 2.) Cu / 1.) 0 deg C, 30 min, 2.) EtOH, from 60 deg C to 75 deg C, 3 h
With
sulfuric acid; hydrogen; iodine; copper; sodium hydrogencarbonate; sodium nitrite;
palladium on activated charcoal;
In
ethyl acetate;
DOI:10.1021/jm980435l
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / K2CO3 / acetone / 6 h / Heating
2: 99 percent / H2 / 10 percent Pd/C / ethyl acetate
3: 64 percent / I2, aq. NaHCO3 / Ambient temperature
4: 1.) aq. NaNO2, H2SO4, 2.) Cu / 1.) 0 deg C, 30 min, 2.) EtOH, from 60 deg C to 75 deg C, 3 h
With
sulfuric acid; hydrogen; iodine; copper; sodium hydrogencarbonate; potassium carbonate; sodium nitrite;
palladium on activated charcoal;
In
ethyl acetate; acetone;
DOI:10.1021/jm980435l