Technology Process of 1,3-difluoro-4-iodo-2-methoxybenzene
There total 5 articles about 1,3-difluoro-4-iodo-2-methoxybenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 96 percent / HNO3 / acetic acid / 15 - 20 °C
2: 94 percent / K2CO3 / acetone / 6 h / Heating
3: 99 percent / H2 / 10 percent Pd/C / ethyl acetate
4: 64 percent / I2, aq. NaHCO3 / Ambient temperature
5: 1.) aq. NaNO2, H2SO4, 2.) Cu / 1.) 0 deg C, 30 min, 2.) EtOH, from 60 deg C to 75 deg C, 3 h
With
sulfuric acid; hydrogen; iodine; nitric acid; copper; sodium hydrogencarbonate; potassium carbonate; sodium nitrite;
palladium on activated charcoal;
In
acetic acid; ethyl acetate; acetone;
DOI:10.1021/jm980435l
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 99 percent / H2 / 10 percent Pd/C / ethyl acetate
2: 64 percent / I2, aq. NaHCO3 / Ambient temperature
3: 1.) aq. NaNO2, H2SO4, 2.) Cu / 1.) 0 deg C, 30 min, 2.) EtOH, from 60 deg C to 75 deg C, 3 h
With
sulfuric acid; hydrogen; iodine; copper; sodium hydrogencarbonate; sodium nitrite;
palladium on activated charcoal;
In
ethyl acetate;
DOI:10.1021/jm980435l
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 94 percent / K2CO3 / acetone / 6 h / Heating
2: 99 percent / H2 / 10 percent Pd/C / ethyl acetate
3: 64 percent / I2, aq. NaHCO3 / Ambient temperature
4: 1.) aq. NaNO2, H2SO4, 2.) Cu / 1.) 0 deg C, 30 min, 2.) EtOH, from 60 deg C to 75 deg C, 3 h
With
sulfuric acid; hydrogen; iodine; copper; sodium hydrogencarbonate; potassium carbonate; sodium nitrite;
palladium on activated charcoal;
In
ethyl acetate; acetone;
DOI:10.1021/jm980435l
