Benzoic acid (2S,3S)-4-{(2S,6R)-6-[(E)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxycarbonyl-hex-4-enyl]-3,6-dihydro-2H-pyran-2-yl}-3-methoxy-2-methyl-butyl ester

Base Information

Chemical Name:Benzoic acid (2S,3S)-4-{(2S,6R)-6-[(E)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxycarbonyl-hex-4-enyl]-3,6-dihydro-2H-pyran-2-yl}-3-methoxy-2-methyl-butyl ester
CAS No.:180592-94-3
Molecular Formula:C₃₂H₅₀O₇Si
Molecular Weight:574.83
Hs Code.:

Benzoic acid (2S,3S)-4-{(2S,6R)-6-[(E)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxycarbonyl-hex-4-enyl]-3,6-dihydro-2H-pyran-2-yl}-3-methoxy-2-methyl-butyl ester

Synonyms:Benzoic acid (2S,3S)-4-{(2S,6R)-6-[(E)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxycarbonyl-hex-4-enyl]-3,6-dihydro-2H-pyran-2-yl}-3-methoxy-2-methyl-butyl ester

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Chemical Property of Benzoic acid (2S,3S)-4-{(2S,6R)-6-[(E)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxycarbonyl-hex-4-enyl]-3,6-dihydro-2H-pyran-2-yl}-3-methoxy-2-methyl-butyl ester

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Technology Process of Benzoic acid (2S,3S)-4-{(2S,6R)-6-[(E)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxycarbonyl-hex-4-enyl]-3,6-dihydro-2H-pyran-2-yl}-3-methoxy-2-methyl-butyl ester

There total 12 articles about Benzoic acid (2S,3S)-4-{(2S,6R)-6-[(E)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxycarbonyl-hex-4-enyl]-3,6-dihydro-2H-pyran-2-yl}-3-methoxy-2-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 69739-34-0
t-butyldimethylsiyl triflate

: 180592-93-2
Benzoic acid (2S,3S)-4-[(2S,6R)-6-((E)-(S)-2-hydroxy-5-methoxycarbonyl-hex-4-enyl)-3,6-dihydro-2H-pyran-2-yl]-3-methoxy-2-methyl-butyl ester

: 180592-94-3
Benzoic acid (2S,3S)-4-{(2S,6R)-6-[(E)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxycarbonyl-hex-4-enyl]-3,6-dihydro-2H-pyran-2-yl}-3-methoxy-2-methyl-butyl ester

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; for 1h; Ambient temperature;

Reference yield:

: 98-88-4
benzoyl chloride

: 180592-94-3
Benzoic acid (2S,3S)-4-{(2S,6R)-6-[(E)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxycarbonyl-hex-4-enyl]-3,6-dihydro-2H-pyran-2-yl}-3-methoxy-2-methyl-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 97 percent / Et₃N, 4-DMAP / CH₂Cl₂ / 3 h / Ambient temperature

2: 4-methylmorpholine N-oxide, aq. OsO₄ / acetone / 2 h / Ambient temperature

3: 83 percent / Pb(OAc)4 / benzene / 1 h / 0 °C

4: 75 percent / Ti(OiPr)4, TiCl₄ / toluene / 3 h / -78 °C

5: 96 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / Ambient temperature

With 2,6-dimethylpyridine; lead(IV) acetate; titanium(IV) isopropylate; dmap; osmium(VIII) oxide; titanium tetrachloride; 4-methylmorpholine N-oxide; triethylamine; In dichloromethane; acetone; toluene; benzene;

Reference yield:

: 157758-33-3
(S)-6-[(2S,3S)-2-Methoxy-4-(4-methoxy-benzyloxy)-3-methyl-butyl]-5,6-dihydro-pyran-2-one

: 180592-94-3
Benzoic acid (2S,3S)-4-{(2S,6R)-6-[(E)-(S)-2-(tert-butyl-dimethyl-silanyloxy)-5-methoxycarbonyl-hex-4-enyl]-3,6-dihydro-2H-pyran-2-yl}-3-methoxy-2-methyl-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / Dibal-H / CH₂Cl₂; toluene / 0.33 h / -78 °C

2: 100 percent / BF₃*Et₂O / acetonitrile / 3 h / 0 °C

3: 97 percent / Et₃N, 4-DMAP / CH₂Cl₂ / 3 h / Ambient temperature

4: 4-methylmorpholine N-oxide, aq. OsO₄ / acetone / 2 h / Ambient temperature

5: 83 percent / Pb(OAc)4 / benzene / 1 h / 0 °C

6: 75 percent / Ti(OiPr)4, TiCl₄ / toluene / 3 h / -78 °C

7: 96 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / Ambient temperature

With 2,6-dimethylpyridine; lead(IV) acetate; titanium(IV) isopropylate; dmap; osmium(VIII) oxide; boron trifluoride diethyl etherate; titanium tetrachloride; diisobutylaluminium hydride; 4-methylmorpholine N-oxide; triethylamine; In dichloromethane; acetone; toluene; acetonitrile; benzene;