1-<(tert-Butyldimethylsilyloxy)methyl>-2-bromo-3,5-dimethoxybenzene

Base Information

• Chemical Name: 1-<(tert-Butyldimethylsilyloxy)methyl>-2-bromo-3,5-dimethoxybenzene
• CAS No.: 166533-30-8
• Molecular Formula: C₁₅H₂₅BrO₃Si
• Molecular Weight: 361.351
• Mol file: 166533-30-8.mol

Synonyms:1-<(tert-Butyldimethylsilyloxy)methyl>-2-bromo-3,5-dimethoxybenzene

Chemical Property of 1-<(tert-Butyldimethylsilyloxy)methyl>-2-bromo-3,5-dimethoxybenzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-<(tert-Butyldimethylsilyloxy)methyl>-2-bromo-3,5-dimethoxybenzene

There total 1 articles about 1-<(tert-Butyldimethylsilyloxy)methyl>-2-bromo-3,5-dimethoxybenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-bromo-3,5-dimethoxybenzyl alcohol (74726-76-4) + tert-butyldimethylsilyl chloride (18162-48-6) → 1-<(tert-Butyldimethylsilyloxy)methyl>-2-bromo-3,5-dimethoxybenzene (166533-30-8)

Guidance literature:

With 1H-imidazole; In N,N-dimethyl-formamide; for 18h; Ambient temperature;

DOI:10.1021/jo951895e

Reference yield: 26.0%

1-<(tert-Butyldimethylsilyloxy)methyl>-2-bromo-3,5-dimethoxybenzene (166533-30-8) + (-)-(4S)-4-isopropyl-2-(2,3-dimethoxy-5-methylphenyl)-4,5-dihydrooxazole (227089-87-4) → (4'S)-2-(4'-isopropyl-4',5'-dihydrooxazol-2'-yl)-6-methoxy-4-methylphenol + (S,4S)-4-isopropyl-2-[2',4',6-trimethoxy-4-methyl-6'-(t-butyldimethylsilyloxy)methyl-1,1'-biphenyl-2-yl]-4,5-dihydrooxazole + (R,4S)-4-isopropyl-2-[2',4',6-trimethoxy-4-methyl-6'-(t-butyldimethylsilyloxy)methyl-1,1'-biphenyl-2-yl]-4,5-dihydrooxazole

Guidance literature:

1-<(tert-Butyldimethylsilyloxy)methyl>-2-bromo-3,5-dimethoxybenzene; With magnesium; In tetrahydrofuran;

(-)-(4S)-4-isopropyl-2-(2,3-dimethoxy-5-methylphenyl)-4,5-dihydrooxazole; In tetrahydrofuran; for 20h; Title compound not separated from byproducts; Heating;

DOI:10.1071/CH99134

Reference yield: 6.0%

1-<(tert-Butyldimethylsilyloxy)methyl>-2-bromo-3,5-dimethoxybenzene (166533-30-8) + (-)-(4S)-4-Isopropyl-2-(1,4,5-trimethoxy-2-naphthyl)-4,5-dihydrooxazole (166533-29-5) → (-)-(R,4S)-2-<1-<4,6-Dimethoxy-2-<(tert-butyldimethylsilyloxy)methyl>phenyl>-4,5-dimethoxy-2-naphthyl>-4-isopropyl-4,5-dihydrooxazole + (S,4S)-2-<1-<4,6-Dimethoxy-2-<(tert-butyldimethylsilyloxy)methyl>phenyl>-4,5-dimethoxy-2-naphthyl>-4-isopropyl-4,5-dihydrooxazole

Guidance literature:

With magnesium; ethylene dibromide; In tetrahydrofuran; 1.) reflux, 1 h, 2.) reflux, 15 h;

DOI:10.1021/jo00122a067

upstream raw materials:

2-bromo-3,5-dimethoxybenzyl alcohol

tert-butyldimethylsilyl chloride

Downstream raw materials:

5-[3,5-dimethoxy-2-(tert-butyl)dimethylsilyloxymethyl-phenyl]-furan-2-aldehyde

5-[4,6-dimethoxy-2-(tert-butyl)dimethylsilyloxymethyl-phenyl]-2-vinyl-furan