2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)benzofuran-3-carboxamide

Base Information

Chemical Name:2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)benzofuran-3-carboxamide
CAS No.:1426960-32-8
Molecular Formula:C₃₂H₂₅FN₄O₅S
Molecular Weight:596.639
Hs Code.:

Synonyms:2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)benzofuran-3-carboxamide

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Chemical Property of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)benzofuran-3-carboxamide

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Technology Process of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)benzofuran-3-carboxamide

There total 15 articles about 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)benzofuran-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.1%

: 1333340-17-2
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzofuran-3-carboxamide

: 1426960-50-0
2-chloro-6H-pyrido[2',3': 5,6][1,3]oxazino[3,4-a]indole

: 1426960-32-8
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)benzofuran-3-carboxamide

Guidance literature:: With potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos; In 1,4-dioxane; water; at 110 ℃; for 3h;

Reference yield:

: 148493-34-9
(2,6-dichloropyridin-3-yl)boronic acid

: 1426960-32-8
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1: dihydrogen peroxide / dichloromethane; water / 0.15 h / 0 - 20 °C

2: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

3: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere

4: boron tribromide / dichloromethane / 3 h / -78 - 20 °C

5: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 100 °C

6: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / water; 1,4-dioxane / 3 h / 110 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; dihydrogen peroxide; boron tribromide; potassium carbonate; XPhos; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 52764-11-1
2,6-dichloro-3-hydroxypyridine

: 1426960-32-8
2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(6H-pyrido[2',3':5,6][1,3]oxazino[3,4-a]indol-2-yl)benzofuran-3-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 80 °C

2: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate / N,N-dimethyl-formamide / 15 h / 60 °C / Inert atmosphere

3: boron tribromide / dichloromethane / 3 h / -78 - 20 °C

4: potassium carbonate / N,N-dimethyl-formamide / 0.5 h / 100 °C

5: potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; XPhos / water; 1,4-dioxane / 3 h / 110 °C

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium phosphate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; boron tribromide; potassium carbonate; XPhos; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;