(R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-pheny1-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate

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Chemical Name:(R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-pheny1-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate
CAS No.:1426655-65-3
Molecular Formula:C₃₆H₃₉FN₂O₅
Molecular Weight:598.714
Hs Code.:

Synonyms:(R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-pheny1-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate

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Chemical Property of (R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-pheny1-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate

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Technology Process of (R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-pheny1-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate

There total 3 articles about (R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-pheny1-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: (E)-isopropyl 7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-5-hydroxy-3-oxohept-6-enoate

: 1426655-65-3
(R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-pheny1-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate

Guidance literature:: With 5%-palladium/activated carbon; hydrogen; In methanol; for 12h; under 760.051 Torr; Inert atmosphere;
DOI:10.1039/c6ra15304f

Reference yield:

: 674-82-8,2130-41-8
4-methyleneoxetan-2-one

: 546-68-9
titanium(IV) isopropylate

: 110862-46-9
5-(4-fluorophenyl)-2-(1-methylethyl)-1-(3-oxopropyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide

: (S)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-pheny1-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate

: 1426655-65-3
(R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-pheny1-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate

Guidance literature:: titanium(IV) isopropylate; With (S)-2-(N-3-tert-butylsalicylidene)amino-3-methyl-1-butanol; In dichloromethane; for 1h; Inert atmosphere;

4-methyleneoxetan-2-one; 5-(4-fluorophenyl)-2-(1-methylethyl)-1-(3-oxopropyl)-N,4-diphenyl-1H-pyrrole-3-carboxamide; In dichloromethane; at -40 ℃; for 48h; Inert atmosphere;

With hydrogenchloride; In diethyl ether; dichloromethane; water; at 20 ℃; for 1h; Reagent/catalyst; Temperature; Time; Overall yield = 62 %; Overall yield = 185.7 mg; enantioselective reaction; Catalytic behavior;
DOI:10.1016/j.tetasy.2012.12.009

Reference yield:

: 1-(3,3-diethoxypropyl)-5-(4-fluoropheny)-2-(1-methylethy)-N,4-diphenyl-1H-pyrrole-3-carboxamide

: 1426655-65-3
(R)-isopropyl 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-pheny1-4-[(phenylamino)carbonyl]-1H-pyrrol-1-yl]-5-hydroxy-3-oxoheptanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / water / 1 h / Reflux

2.1: (S)-2-(N-3-tert-butylsalicylidene)amino-3-methyl-1-butanol / dichloromethane / 1 h / Inert atmosphere

2.2: 48 h / -40 °C / Inert atmosphere

2.3: 1 h / 20 °C

With hydrogenchloride; (S)-2-(N-3-tert-butylsalicylidene)amino-3-methyl-1-butanol; In dichloromethane; water; 2.2: |Aldol Condensation;
DOI:10.1016/j.tetasy.2012.12.009