4''-O-benzyl-9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal

Base Information

Chemical Name:4''-O-benzyl-9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal
CAS No.:190059-57-5
Molecular Formula:C₆₀H₁₀₇NO₁₃Si₃
Molecular Weight:1134.76
Hs Code.:

Synonyms:4''-O-benzyl-9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal

Suppliers and Price of 4''-O-benzyl-9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of 4''-O-benzyl-9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 4''-O-benzyl-9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal

There total 4 articles about 4''-O-benzyl-9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 100-39-0
benzyl bromide

: 161821-05-2
9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal

: 190059-57-5
4''-O-benzyl-9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 45 ℃; for 1h;
DOI:10.7164/antibiotics.50.32

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 190059-57-5
4''-O-benzyl-9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / imidazole / dimethylformamide / 24 h / 50 °C

2: 87 percent / NaOH / tetra-n-butylammonium hydrogensulfate / H₂O; benzene / 2 h / 25 °C

3: 90 percent / NaH / dimethylformamide / 1 h / 45 °C

With 1H-imidazole; sodium hydroxide; sodium hydride; tetra(n-butyl)ammonium hydrogensulfate; In water; N,N-dimethyl-formamide; benzene; 1: Substitution / 2: chemoselective saponification / 3: Alkylation;
DOI:10.7164/antibiotics.50.32

Reference yield:

: leucomycin A₇

: 190059-57-5
4''-O-benzyl-9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal

Guidance literature:: Multi-step reaction with 3 steps

1: 83 percent / imidazole / dimethylformamide / 24 h / 50 °C

2: 87 percent / NaOH / tetra-n-butylammonium hydrogensulfate / H₂O; benzene / 2 h / 25 °C

3: 90 percent / NaH / dimethylformamide / 1 h / 45 °C

With 1H-imidazole; sodium hydroxide; sodium hydride; tetra(n-butyl)ammonium hydrogensulfate; In water; N,N-dimethyl-formamide; benzene; 1: Substitution / 2: chemoselective saponification / 3: Alkylation;
DOI:10.7164/antibiotics.50.32