4''-O-benzyl-9,18-di-O-tert-butyldimethylsilyl-3''-O-methylleucomycin V 3,18-acetal

Base Information

Chemical Name:4''-O-benzyl-9,18-di-O-tert-butyldimethylsilyl-3''-O-methylleucomycin V 3,18-acetal
CAS No.:190059-66-6
Molecular Formula:C₅₅H₉₅NO₁₃Si₂
Molecular Weight:1034.53
Hs Code.:

Synonyms:4''-O-benzyl-9,18-di-O-tert-butyldimethylsilyl-3''-O-methylleucomycin V 3,18-acetal

Suppliers and Price of 4''-O-benzyl-9,18-di-O-tert-butyldimethylsilyl-3''-O-methylleucomycin V 3,18-acetal

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 4''-O-benzyl-9,18-di-O-tert-butyldimethylsilyl-3''-O-methylleucomycin V 3,18-acetal

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 4''-O-benzyl-9,18-di-O-tert-butyldimethylsilyl-3''-O-methylleucomycin V 3,18-acetal

There total 6 articles about 4''-O-benzyl-9,18-di-O-tert-butyldimethylsilyl-3''-O-methylleucomycin V 3,18-acetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 190059-57-5
4''-O-benzyl-9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal

: 74-88-4
methyl iodide

: 190059-66-6
4''-O-benzyl-9,18-di-O-tert-butyldimethylsilyl-3''-O-methylleucomycin V 3,18-acetal

Guidance literature:: 4''-O-benzyl-9,18,2'-tri-O-tert-butyldimethylsilylleucomycin V 3,18-acetal; With 3-chloro-benzenecarboperoxoic acid; In chloroform; at 25 ℃; for 0.0833333h;

methyl iodide; With sodium hydride; In N,N-dimethyl-formamide; at 45 ℃; for 1h;

With silica gel; at 25 ℃; for 24h;
DOI:10.7164/antibiotics.50.32

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 190059-66-6
4''-O-benzyl-9,18-di-O-tert-butyldimethylsilyl-3''-O-methylleucomycin V 3,18-acetal

Guidance literature:: Multi-step reaction with 4 steps

1.1: 83 percent / imidazole / dimethylformamide / 24 h / 50 °C

2.1: 87 percent / NaOH / tetra-n-butylammonium hydrogensulfate / H₂O; benzene / 2 h / 25 °C

3.1: 90 percent / NaH / dimethylformamide / 1 h / 45 °C

4.1: m-chloroperoxybenzoic acid / CHCl₃ / 0.08 h / 25 °C

4.2: NaH / dimethylformamide / 1 h / 45 °C

4.3: 51 percent / silica gel / 24 h / 25 °C

With 1H-imidazole; sodium hydroxide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; tetra(n-butyl)ammonium hydrogensulfate; In chloroform; water; N,N-dimethyl-formamide; benzene; 1.1: Substitution / 2.1: chemoselective saponification / 3.1: Alkylation / 4.1: Oxidation / 4.2: Methylation / 4.3: Reduction;
DOI:10.7164/antibiotics.50.32

Reference yield:

: 161821-04-1
9,18,2'-tri-O-tert-butyldimethylsilylleucomycin A₇ 3,18-acetal

: 190059-66-6
4''-O-benzyl-9,18-di-O-tert-butyldimethylsilyl-3''-O-methylleucomycin V 3,18-acetal

Guidance literature:: Multi-step reaction with 3 steps

1.1: 87 percent / NaOH / tetra-n-butylammonium hydrogensulfate / H₂O; benzene / 2 h / 25 °C

2.1: 90 percent / NaH / dimethylformamide / 1 h / 45 °C

3.1: m-chloroperoxybenzoic acid / CHCl₃ / 0.08 h / 25 °C

3.2: NaH / dimethylformamide / 1 h / 45 °C

3.3: 51 percent / silica gel / 24 h / 25 °C

With sodium hydroxide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; tetra(n-butyl)ammonium hydrogensulfate; In chloroform; water; N,N-dimethyl-formamide; benzene; 1.1: chemoselective saponification / 2.1: Alkylation / 3.1: Oxidation / 3.2: Methylation / 3.3: Reduction;
DOI:10.7164/antibiotics.50.32