2294-46-4

Basic information

• Product Name: 2,2'-iminodipropanol
• Synonyms: 2,2'-iminodipropanol;2,2'-Iminobis(1-propanol);Einecs 218-933-9;1-Propanol, 2,2'-iMinobis-;2,2'-Azanediylbis(propan-1-ol)
• CAS NO: 2294-46-4
• Molecular Formula: C₆H₁₅NO₂
• Molecular Weight: 133.1888
• EINECS: 218-933-9
• Mol File: 2294-46-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 254.4 °C at 760 mmHg
• Flash Point: 118.4 °C
• Appearance: /
• Density: 1.007 g/cm³
• Storage Temp.: 2-8°C
• PKA: 14.40±0.10(Predicted)
• CAS DataBase Reference: 2,2'-iminodipropanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2'-iminodipropanol(2294-46-4)
• EPA Substance Registry System: 2,2'-iminodipropanol(2294-46-4)

Safety Data

• Hazardous Substances Data: 2294-46-4(Hazardous Substances Data)

Usage

General Description

2,2'-iminodipropanol is a chemical compound with the formula (HOCH2)2NCH2CH2OH. It is a colorless, viscous liquid that is used as a chemical intermediate in the production of various materials such as pharmaceuticals, surfactants, and water treatment chemicals. It is also used as a corrosion inhibitor in metalworking fluids, and as a stabilizer in the production of chlorinated solvents. 2,2'-iminodipropanol is known for its ability to form complexes with metal ions, which makes it useful in certain chemical processes. It is considered to be a moderately hazardous chemical, and proper safety measures should be taken when handling and storing it.

Upstream product

• 6168-72-5 2-Amino-1-propanol 
• 116-09-6 hydroxy-2-propanone 
• 6170-23-6 dl-2-amino-1-propanol hydrochloride 
• 75-56-9 methyloxirane 

Downstream Products

• 123-57-9 2,6-dimethylmorpholine 
• 1542268-31-4 meso-3,5-Dimethylmorpholine hydrochloride 
• 402832-69-3 (2S,6S)-2,6-dimethyl-piperazine 
• 21655-48-1 cis-2,6-dimethylpiperazine 
• 2815-34-1 2,5-dimethyl-piperazine 
• 59573-44-3 (+)-(2S,5S)-2,5-dimethylpiperazine 

Relevant articles and documents

Method of preparing new propanolamine

The invention provides a method for preparing MNPA, DNPA and TNPA. The method comprises the following steps: taking PO and ammonium chloride as raw materials for reacting; adding water, ammonium chloride and the PO into a reaction kettle; gradually injecting partial PO while stirring; reacting and synthesizing MNPA.HCL and partial DNPA.HCL under the conditions of temperature at 60-80 DEG C and pressure control lower than or equal to 0.3MPa; separating the MNPA.HCL by utilizing the difference of physical property; injecting the remained PO into filtrate; reacting at 70-100 DEG C; cooling, filtering and drying, thereby obtaining TNPA.HCL; merging the cleaning solution with the filtrate, and then dehydrating, thereby obtaining the DNPA.HCL; and respectively reacting the three hydrochlorides with equivalent methanol alkali, thereby obtaining MNPA, DNPA and TNPA. The method has unique advantages; the relative temperature and pressure are lower during the preparation process; the equipment is simple and is low in investment; the main products are easily separated; the raw material PO is prevented from being subjected to side reactions, such as hydrolyzing into propylene glycol, and the like, under an alkali condition; the energy-saving, emission-reducing, low-carbon and environment-friendly effects are achieved; and the only byproduct sodium chloride is used as a self-use raw material for producing the ammonium chloride and sodium bicarbonate with relative high additional value is obtained.

NUCLEAR TRANSPORT MODULATORS AND USES THEREOF

The present invention relates to compounds of formula I: and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the compounds of formula I, and methods of using said compounds, salts and compositions in the treatment of various disorders associated with CRM1 activity.