4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylthio)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

Base Information

Chemical Name:4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylthio)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine
CAS No.:1196886-12-0
Molecular Formula:C₃₀H₃₀N₄O₄S₂
Molecular Weight:574.725
Hs Code.:

Synonyms:4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylthio)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

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Chemical Property of 4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylthio)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

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Technology Process of 4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylthio)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

There total 9 articles about 4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylthio)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 21.0%

: 1196886-10-8
(E)-N-(4-(benzyloxy)-6-chloro-2-(methylthio)pyrimidin-5-yl)-N-(3-(4-methoxy-3,5-dimethylpyridin-2-yl)allyl)-4-methylbenzenesulfonamide

: 1196886-12-0
4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylthio)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: With potassium acetate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In toluene; at 180 ℃; for 0.333333h; Microwave irradiation;

Reference yield:

: 100-51-6,185532-71-2
benzyl alcohol

: 1196886-12-0
4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylthio)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2: n-butyllithium / tetrahydrofuran / -78 °C

3: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

4: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.33 h / 180 °C / Microwave irradiation

With n-butyllithium; potassium acetate; sodium hydride; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; toluene;

Reference yield:

: 86604-78-6
(4-methoxy-3,5-dimethylpyridin-2-yl)methanol

: 1196886-12-0
4-(benzyloxy)-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-2-(methylthio)-5-tosyl-5H-pyrrolo[3,2-d]pyrimidine

Guidance literature:: Multi-step reaction with 5 steps

1: manganese(IV) oxide / chloroform / 0.17 h / 20 °C

2: potassium carbonate / ethanol / 4 h / 70 °C

3: Diisobutyl adipate / tetrahydrofuran / -78 - -7 °C

4: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C

5: potassium acetate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene / 0.33 h / 180 °C / Microwave irradiation

With manganese(IV) oxide; Diisobutyl adipate; potassium acetate; potassium carbonate; triphenylphosphine; diethylazodicarboxylate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; chloroform; toluene;