4-(cyclopentylamino)-2-((2,5-dichlorobenzyl)amino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)pyrimidine-5-carboxamide

Base Information

Chemical Name:4-(cyclopentylamino)-2-((2,5-dichlorobenzyl)amino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)pyrimidine-5-carboxamide
CAS No.:1421367-66-9
Molecular Formula:C₂₄H₃₀Cl₂N₆O₂
Molecular Weight:505.447
Hs Code.:

Synonyms:4-(cyclopentylamino)-2-((2,5-dichlorobenzyl)amino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)pyrimidine-5-carboxamide

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Chemical Property of 4-(cyclopentylamino)-2-((2,5-dichlorobenzyl)amino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)pyrimidine-5-carboxamide

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Technology Process of 4-(cyclopentylamino)-2-((2,5-dichlorobenzyl)amino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)pyrimidine-5-carboxamide

There total 12 articles about 4-(cyclopentylamino)-2-((2,5-dichlorobenzyl)amino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)pyrimidine-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₈H₂₇N₅O₄S

: 10541-69-2
2,5-dichloro-benzylamine

: 1421367-66-9
4-(cyclopentylamino)-2-((2,5-dichlorobenzyl)amino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)pyrimidine-5-carboxamide

Guidance literature:: With triethylamine; In 1,4-dioxane; Reflux;
DOI:10.1016/j.bmcl.2012.12.013

Reference yield:

: 1003-03-8
Cyclopentamine

: 1421367-66-9
4-(cyclopentylamino)-2-((2,5-dichlorobenzyl)amino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / acetonitrile / 80 °C

2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C

3: triethylamine / 1,4-dioxane / Reflux

4: sodium hydroxide; methanol / Reflux

5: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide

With methanol; triethylamine; 3-chloro-benzenecarboperoxoic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2012.12.028

Reference yield:

: 74840-34-9
4-chloro-2-(methylsulfanyl)pyrimidine-5-carboxylic acid

: 1421367-66-9
4-(cyclopentylamino)-2-((2,5-dichlorobenzyl)amino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)pyrimidine-5-carboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 95 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere

2.2: 4 h / 20 °C / Inert atmosphere

3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine / ethanol / 16 h / 90 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.1c00845