Technology Process of 4-(cyclopentylamino)-2-((2,5-dichlorobenzyl)amino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)pyrimidine-5-carboxamide
There total 12 articles about 4-(cyclopentylamino)-2-((2,5-dichlorobenzyl)amino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)pyrimidine-5-carboxamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 5 steps
1: triethylamine / acetonitrile / 80 °C
2: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 0 °C
3: triethylamine / 1,4-dioxane / Reflux
4: sodium hydroxide; methanol / Reflux
5: triethylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide
With
methanol; triethylamine; 3-chloro-benzenecarboperoxoic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; sodium hydroxide;
In
1,4-dioxane; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2012.12.028
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 16 h / 95 °C / Inert atmosphere
2.1: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 1 h / 20 °C / Inert atmosphere
2.2: 4 h / 20 °C / Inert atmosphere
3.1: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 4 h / 0 - 20 °C / Inert atmosphere
4.1: N-ethyl-N,N-diisopropylamine / ethanol / 16 h / 90 °C / Inert atmosphere
With
N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate;
In
ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/acs.jmedchem.1c00845