Technology Process of 2-(5-(tert-butyl)-2-methoxyphenyl)-5-methylpyridine
There total 4 articles about 2-(5-(tert-butyl)-2-methoxyphenyl)-5-methylpyridine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2-Bromo-5-methylpyridine; (5-(tert-butyl)-2-methoxyphenyl)boronic acid;
With
potassium carbonate;
In
1,2-dimethoxyethane; water;
for 0.333333h;
Inert atmosphere;
With
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; water;
at 80 ℃;
for 22h;
Inert atmosphere;
Sealed tube;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: bromine / chloroform; tetrachloromethane / 0 °C / Inert atmosphere
2.1: potassium carbonate / acetone / 22 h / Inert atmosphere; Reflux
3.1: n-butyllithium / tetrahydrofuran; hexane / 4.5 h / -78 - 0 °C / Inert atmosphere
4.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere
4.2: 22 h / 80 °C / Inert atmosphere; Sealed tube
With
n-butyllithium; bromine; potassium carbonate;
In
tetrahydrofuran; tetrachloromethane; 1,2-dimethoxyethane; hexane; chloroform; water; acetone;
4.1: |Suzuki Coupling / 4.2: |Suzuki Coupling;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate / acetone / 22 h / Inert atmosphere; Reflux
2.1: n-butyllithium / tetrahydrofuran; hexane / 4.5 h / -78 - 0 °C / Inert atmosphere
3.1: potassium carbonate / 1,2-dimethoxyethane; water / 0.33 h / Inert atmosphere
3.2: 22 h / 80 °C / Inert atmosphere; Sealed tube
With
n-butyllithium; potassium carbonate;
In
tetrahydrofuran; 1,2-dimethoxyethane; hexane; water; acetone;
3.1: |Suzuki Coupling / 3.2: |Suzuki Coupling;
